期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 20, 期 11, 页码 1827-1850出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2013.5341
关键词
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资金
- European Union [POIG 01.01.02-00-109/09, 01.01.02.069/09, POIG.02.01.00-12-064/08, POIG.02.02.00-014/08]
- Ministry of Science and Higher Education [N N301 035240]
- National Centre for Science [NCN 2012/06/M/NZ1/00008]
- Ministry of Science and Higher Education
- Foundation for Polish Science
Significance: Heme oxygenase-1 (HO-1) converts heme to biliverdin, carbon monoxide, and ferrous ions, but its cellular functions are far beyond heme metabolism. HO-1 via heme removal and degradation products acts as a cytoprotective, anti-inflammatory, immunomodulatory, and proangiogenic protein, regulating also a cell cycle. Additionally, HO-1 can translocate to nucleus and regulate transcription factors, so it can also act independently of enzymatic function. Recent Advances: Recently, a body of evidence has emerged indicating a role for HO-1 in postnatal differentiation of stem and progenitor cells. Maturation of satellite cells, skeletal myoblasts, adipocytes, and osteoclasts is inhibited by HO-1, whereas neurogenic differentiation and formation of cardiomyocytes perhaps can be enhanced. Moreover, HO-1 influences a lineage commitment in pluripotent stem cells and maturation of hematopoietic cells. It may play a role in development of osteoblasts, but descriptions of its exact effects are inconsistent. Critical Issues: In this review we discuss a role of HO-1 in cell differentiation, and possible HO-1-dependent signal transduction pathways. Among the potential mediators, we focused on microRNA (miRNA). These small, noncoding RNAs are critical for cell differentiation. Recently we have found that HO-1 not only influences expression of specific miRNAs but also regulates miRNA processing enzymes. Future Directions: It seems that interplay between HO-1 and miRNAs may be important in regulating fates of stem and progenitor cells and needs further intensive studies. Antioxid. Redox Signal. 20, 1827-1850.
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