期刊
MICROBES AND INFECTION
卷 7, 期 13, 页码 1370-1375出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2005.06.002
关键词
visceral leishmaniasis; organ transplantation; immunosuppression; France
Eleven new cases of visceral leishmaniasis (VL) are reported in organ transplant patients in France. The epidemiological, clinical, biological, diagnostic and therapeutic features are reviewed, based on these cases and 46 cases reported in the literature. VL was most commonly associated with renal transplantation (77% of the cases). Most patients were from Southern European countries. The main clinical symptom was fever. Leucopoenia and anaemia were the most frequent haematological disorders. Diagnosis was by direct finding of the parasite in smears of bone marrow (85.2%) or, by positive serology (90.9%). Without antileishmanial treatment, VL in transplant recipients was fatal. Treatment using either antimonials or amphotericine B gave similar cure rates of around 80% of the cases. But toxicity was higher for antimonials. Relapses occurred in 14.3%. (c) 2005 Elsevier SAS. All rights reserved.
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