期刊
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
卷 20, 期 5, 页码 409-415出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/14756360500179762
关键词
acetylcholinesterase; reactivation; pesticide; chlorpyrifos; reactivator; oxime; inhibition; AChE
Nine potential AChE reactivators were synthesized using a modification of currently known synthetic pathways. Their potency to reactivate AChE inhibited by insecticide chlorpyrifos was tested in vitro. 2,2'-Bis(hydroxyiminomethyl)-1,1'-(1,4-phenylenedimethyl)-bispyridinium dibromide seems to be the most potent AChE reactivator. The reactivation potency of these compounds depends on structural factors such as length of the linking chain between both pyridinium rings and position of the oxime moiety on the pyridinium ring.
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