期刊
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
卷 142, 期 1, 页码 167-171出版社
WILEY
DOI: 10.1111/j.1365-2249.2005.02891.x
关键词
recurrent vaginal candidiasis; immune regulation; atopy; cytokines; IgE
类别
资金
- NIAID NIH HHS [P50 AI030639, AI-30639] Funding Source: Medline
To determine whether there is an association between atopy and recurrent vaginal candidiasis (RVC) and to evaluate the type-2 immune response in patients with RVC. Evaluation of immediate hypersensitivity skin tests to aeroallergens, measurement of total IgE and Candida albicans specific IgE and levels of IL-5 in 44 women with RVC and 26 with sporadic vaginal candidiasis (SVC). Statistical analyses were performed by Mann-Whitney test and chi(2) test with Yates correction. History of atopy (68%) and positive skin test (42%) were higher (P < 0.05) in RVC than in patients with SVC. No significant difference was found in total IgE, C. albicans specific IgE and IL-5 levels. There was a strong association between atopy and RVC, but type-2 immune response to C. albicans antigen was absent or similar in the two groups of patients.
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