期刊
CURRENT DIRECTIONS IN PSYCHOLOGICAL SCIENCE
卷 14, 期 5, 页码 229-233出版社
SAGE PUBLICATIONS INC
DOI: 10.1111/j.0963-7214.2005.00370.x
关键词
maternal care; stress responses; epigenesis; stress hormones; individual differences
Familial transmission of mental illness is common. Recent studies in behavioral neuroscience and biological psychiatry reveal the importance of epigenetic mechanisms of transmission that center on the developmental consequences of variations in parental care. Studies with rats suggest that environmental adversity results in patterns of parent-offspring interactions that increase stress reactivity through sustained effects on gene expression in brain regions known to regulate behavioral, endocrine, and autonomic responses to stress. While such effects might be adaptive, the associated cost involves an increased risk for stress-related illness.
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