期刊
CHEST
卷 128, 期 4, 页码 2025-2034出版社
ELSEVIER SCIENCE BV
DOI: 10.1378/chest.128.4.2025
关键词
dynamic hyperinflation; endurance; exercise training; rehabilitation; respiratory rate
Study objectives: We hypothesized that endurance exercise training would reduce the degree of hyperinflation for a given level of exercise and thereby improve submaximal exercise endurance. Methods: Twenty-four patients with COPD (mean FEV1, 36.4 +/- 8.5% of predicted [+/- SD]) undertook a high-intensity cycle ergometer exercise training program for 45 min, three times a week for 7 weeks. Before and after training, the patients performed both an incremental exercise test to maximum and a constant work rate (CWR) test on a cycle ergonicter at 75% of the peak work rate obtained in the pretraining incremental test. Ventilatory variables were measured breath-by-breath, and inspiratory capacity (IC) was measured every 2 min to assess changes in end-expiratory lung volume. Results: After training, the increase in peak oxygen uptake was not statistically significant; however, the peak work rate increased by, 12.9 +/- 10.3 W (p < 0.01). For the CWR test performed at the same work rate both before and after training, ventilation and breathing frequency (f) were lower after training (average, 1.97 L/min and 3.2 breaths/min, respectively; p < 0.01) and IC was greater (by an average of 133 mL, p < 0.05), signifying decreased hyperinflation. The increase in IC at the point of termination in the shortest CWR test for each individual (defined as isotime) correlated well with both the decreased f (r = 0.63, p = 0.001) and with the increase in CWR exercise endurance (average, 13.1 min, r = 0.46, p = 0.023). Conclusions: Exercise training in patients with severe COPD dramatically improves submaximal exercise endurance. Decreased dynamic hyperinflation may in part, mediate the improvement in exercise endurance by delaying the attainment of a critically high inspiratory lung volume.
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