期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 14, 期 5, 页码 881-+出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2010.3375
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资金
- University of Padova
- Fondazione CARIPARO
- Ministero dell'Istruzione, dell'Universita della Ricerca (MIUR)
- Consiglio Nazionale delle Ricerche
Mitochondrial damage is a determining factor in causing loss of cardiomyocyte function and viability, yet a mild degree of mitochondrial dysfunction appears to underlie cardioprotection against injury caused by postischemic reperfusion. This review is focused on two major mechanisms of mitochondrial dysfunction, namely, oxidative stress and opening of the mitochondrial permeability transition pore. The formation of reactive oxygen species in mitochondria will be analyzed with regard to factors controlling mitochondrial permeability transition pore opening. Finally, these mitochondrial processes are analyzed with respect to cardioprotection afforded by ischemic pre- and postconditioning. Antioxid. Redox Signal. 14, 881-891.
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