期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 12, 期 9, 页码 1065-1077出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2009.2945
关键词
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资金
- Ministry of Science and Technology of China [2010CB912601, 2009ZX09303-006]
- National Natural Science Foundation of China [30825016]
- Natural Science Foundation of Shanghai [09XD1400400]
It is not known whether H2S can promote angiogenesis with improvement of regional blood flow in ischemic organs. Sodium hydrosulfide (NaHS, a H2S donor) was administered once a day for 4w following femoral artery ligation. Collateral vessel growth, capillary density, regional tissue blood flow, the expression of endothelial growth factor (VEGF), VEGF receptor 2 (VEGFR2) and Akt were examined during or at the end of the treatment period. NaHS treatment significantly increased collateral vessel growth, capillary density, and regional tissue blood flow in ischemic hind limb muscles compared with the controls. These effects were associated with an increase in VEGF expression in the skeletal muscles and VEGFR2 phosphorylation in the neighboring vascular endothelial cells, suggesting a role of VEGF in mediating the NaHS effects in a cell-cell interaction pattern. Moreover, NaHS treatment also resulted in an increase in Akt phosphorylation in ischemic hind limb muscles. In conclusion, our observations with NaHS strongly suggest that H2S is a proangiogenic factor in chronic ischemia. The proangiogenic effect of NaHS may be mediated by interaction between the upregulated VEGF in the skeletal muscle cells and the VEGFR2 as well as its downstream signaling element Akt in the vascular endothelial cells. Antioxid. Redox Signal. 12, 1065-1077.
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