期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 12, 期 11, 页码 1247-1269出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2009.2698
关键词
-
资金
- National Institutes of Health, National Cancer Institute [CA114571, CA94025, CA106298, CA121168]
- Riley Children's Foundation
Redox reactions are known to regulate many important cellular processes. In this review, we focus on the role of redox regulation in DNA repair both in direct regulation of specific DNA repair proteins as well as indirect transcriptional regulation. A key player in the redox regulation of DNA repair is the base excision repair enzyme apurinic/apyrimidinic endonuclease 1 (APE1) in its role as a redox factor. APE1 is reduced by the general redox factor thioredoxin, and in turn reduces several important transcription factors that regulate expression of DNA repair proteins. Finally, we consider the potential for chemotherapeutic development through the modulation of APE1's redox activity and its impact on DNA repair. Antioxid. Redox Signal. 12, 1247-1269.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据