相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。A phase II trial of talampanel in subjects with amyotrophic lateral sclerosis
Robert M. Pascuzzi et al.
AMYOTROPHIC LATERAL SCLEROSIS (2010)
Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
Adam K. Walker et al.
BRAIN (2010)
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo (vol 19, pg 671, 2010)
Edor Kabashi et al.
HUMAN MOLECULAR GENETICS (2010)
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis
Lucia Corrado et al.
JOURNAL OF MEDICAL GENETICS (2010)
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Sami J. Barmada et al.
JOURNAL OF NEUROSCIENCE (2010)
Global Analysis of TDP-43 Interacting Proteins Reveals Strong Association with RNA Splicing and Translation Machinery
Brian D. Freibaum et al.
JOURNAL OF PROTEOME RESEARCH (2010)
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
Michael J. Strong
JOURNAL OF THE NEUROLOGICAL SCIENCES (2010)
Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
Xiaoju Wang et al.
NEUROSCIENCE LETTERS (2010)
Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies
Jun Hee Lee et al.
SCIENCE (2010)
TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
Michael A. Gitcho et al.
ACTA NEUROPATHOLOGICA (2009)
ER and aging-Protein folding and the ER stress response
Nirinjini Naidoo
AGEING RESEARCH REVIEWS (2009)
Dysfunction of the unfolded protein response increases neurodegeneration in aged rat hippocampus following proteasome inhibition
Maria Paz Gavilan et al.
AGING CELL (2009)
Deleterious Variants of FIG4. a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
Chiara Pizzasegola et al.
AMYOTROPHIC LATERAL SCLEROSIS (2009)
Regulation Mechanisms and Signaling Pathways of Autophagy
Congcong He et al.
ANNUAL REVIEW OF GENETICS (2009)
Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis
Jordi Magrane et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Mechanisms and Implications of Reactive Oxygen Species Generation During the Unfolded Protein Response: Roles of Endoplasmic Reticulum Oxidoreductases, Mitochondrial Electron Transport, and NADPH Oxidase
Celio X. C. Santos et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
Aggregation of Copper-Zinc Superoxide Dismutase in Familial and Sporadic ALS
Madhuri Chattopadhyay et al.
ANTIOXIDANTS & REDOX SIGNALING (2009)
XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagy
Soledad Matus et al.
AUTOPHAGY (2009)
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PlKfyve underPPIn endo-lysosome function
Stephen K. Dove et al.
BIOCHEMICAL JOURNAL (2009)
Two Disaccharides and Trimethylamine N-Oxide Affect Aβ Aggregation Differently, but All Attenuate Oligomer-Induced Membrane Permeability
Wei Qi et al.
BIOCHEMISTRY (2009)
Effects of partial suppression of parkin on huntingtin mutant R6/1 mice
Isabel Rubio et al.
BRAIN RESEARCH (2009)
Protective effect against Parkinson's disease-related insults through the activation of XBP1
Megumi Sado et al.
BRAIN RESEARCH (2009)
Rethinking ALS: The FUS about TDP-43
Clotilde Lagier-Tourenne et al.
CELL (2009)
IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates
Dan Han et al.
CELL (2009)
The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
J. M. Vicencio et al.
CELL DEATH AND DIFFERENTIATION (2009)
Endoplasmic Reticulum Protein Quality Control in Neurodegenerative Disease: The Good, the Bad and the Therapy
Wiep Scheper et al.
CURRENT MEDICINAL CHEMISTRY (2009)
Mitochondrial apoptosis induced by BH3-only molecules in the exclusive presence of endoplasmic reticular Bak
Martina Klee et al.
EMBO JOURNAL (2009)
Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins
Daisuke Oikawa et al.
EXPERIMENTAL CELL RESEARCH (2009)
The mitochondrial permeability transition pore in motor neurons: Involvement in the pathobiology of ALS mice
Lee J. Martin et al.
EXPERIMENTAL NEUROLOGY (2009)
Autophagy for the avoidance of neurodegeneration
Frank Madeo et al.
GENES & DEVELOPMENT (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz et al.
GENES & DEVELOPMENT (2009)
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
Cole J. Ferguson et al.
HUMAN MOLECULAR GENETICS (2009)
Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease
Mercedes Prudencio et al.
HUMAN MOLECULAR GENETICS (2009)
Chemical Biology Investigation of Cell Death Pathways Activated by Endoplasmic Reticulum Stress Reveals Cytoprotective Modulators of ASK1
InKi Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress
Truyen Nguyen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
Anne Simonsen et al.
JOURNAL OF CELL BIOLOGY (2009)
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
Jeong-Sun Ju et al.
JOURNAL OF CELL BIOLOGY (2009)
Regulated Ire1-dependent decay of messenger RNAs in mammalian cells
Julie Hollien et al.
JOURNAL OF CELL BIOLOGY (2009)
How do ESCRT proteins control autophagy?
Tor Erik Rusten et al.
JOURNAL OF CELL SCIENCE (2009)
Control of mitochondrial apoptosis by the Bcl-2 family
Joslyn K. Brunelle et al.
JOURNAL OF CELL SCIENCE (2009)
Sequestosome 1/p62 links familial ALS mutant SOD1 to LC3 via an ubiquitin-independent mechanism
Jozsef Gal et al.
JOURNAL OF NEUROCHEMISTRY (2009)
ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB
Hiroaki Suzuki et al.
JOURNAL OF NEUROCHEMISTRY (2009)
TDP-43 is recruited to stress granules in conditions of oxidative insult
Claudia Colombrita et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis
Yvonne S. Yang et al.
JOURNAL OF NEUROSCIENCE (2009)
BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α
Fernanda Lisbona et al.
MOLECULAR CELL (2009)
Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome
Claudio Hetz et al.
MOLECULAR CELL (2009)
Discovery of Atg5/Atg7-independent alternative macroautophagy
Yuya Nishida et al.
NATURE (2009)
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison et al.
NATURE (2009)
A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
Smita Saxena et al.
NATURE NEUROSCIENCE (2009)
Genetics of motor neuron disorders: new insights into pathogenic mechanisms
Patrick A. Dion et al.
NATURE REVIEWS GENETICS (2009)
Dynamics and diversity in autophagy mechanisms: lessons from yeast
Hitoshi Nakatogawa et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Converging concepts of protein folding in vitro and in vivo
F. Ulrich Hartl et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2009)
Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
Jennifer L. Tomic et al.
NEUROBIOLOGY OF DISEASE (2009)
Wild-type Cu/Zn superoxide dismutase (SOD1) does not facilitate, but impedes the formation of protein aggregates of amyotrophic lateral sclerosis causing mutant SOD1
Heidrun Witan et al.
NEUROBIOLOGY OF DISEASE (2009)
Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice
Yasushi Ito et al.
NEUROBIOLOGY OF DISEASE (2009)
Another gene for ALS Mutations in sporadic cases and the rare variant hypothesis
Kevin Talbot
NEUROLOGY (2009)
Mutations in FUS cause FALS and SALS in French and French Canadian populations
V. V. Belzil et al.
NEUROLOGY (2009)
Divergent Effects of PERK and IRE1 Signaling on Cell Viability
Jonathan H. Lin et al.
PLOS ONE (2009)
No Benefit from Chronic Lithium Dosing in a Sibling-Matched, Gender Balanced, Investigator-Blinded Trial Using a Standard Mouse Model of Familial ALS
Alan Gill et al.
PLOS ONE (2009)
Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS
Celeste M. Karch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
Iga Wegorzewska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
Dong-Hyung Cho et al.
SCIENCE (2009)
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Colin Selman et al.
SCIENCE (2009)
Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
Caroline Vance et al.
SCIENCE (2009)
Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
T. J. Kwiatkowski et al.
SCIENCE (2009)
Destabilizing Protein Polymorphisms in the Genetic Background Direct Phenotypic Expression of Mutant SOD1 Toxicity
Tali Gidalevitz et al.
PLOS GENETICS (2009)
Evaluation of the Golgi trafficking protein VPS54 (wobbler) as a candidate for ALS
Miriam H. Meisler et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Lithium therapy in ALS
Vincent Meininger et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
Creatine monohydrate in ALS: Effects on strength, fatigue, respiratory status and ALSFRS
Jeffrey Rosenfeld et al.
AMYOTROPHIC LATERAL SCLEROSIS (2008)
The Role of Mitochondria in Reactive Oxygen Species Metabolism and Signaling
Anatoly A. Starkov
MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS (2008)
Amyotrophic lateral sclerosis: From current developments in the laboratory to clinical implications
Mauro Cozzolino et al.
ANTIOXIDANTS & REDOX SIGNALING (2008)
Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome
Wen-Xing Ding et al.
AUTOPHAGY (2008)
Altered macroautophagy in the spinal cord of S0D1 mutant mice
Liang Li et al.
AUTOPHAGY (2008)
Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae
Hessun Cheong et al.
AUTOPHAGY (2008)
Oligomers of the amyloid-β protein disrupt working memory:: Confirmation with two behavioral procedures
Alan Poling et al.
BEHAVIOURAL BRAIN RESEARCH (2008)
Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior
Dennis J. Selkoe
BEHAVIOURAL BRAIN RESEARCH (2008)
Trehalose impairs aggregation of PrPSc molecules and protects prion-infected cells against oxidative damage
Florence Beranger et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Real-Time Redox Measurements during Endoplasmic Reticulum Stress Reveal Interlinked Protein Folding Functions
Philip I. Merksamer et al.
CELL (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity
Gabriella Dobrowolny et al.
CELL METABOLISM (2008)
The stress rheostat:: An interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration
Soledad Matus et al.
CURRENT MOLECULAR MEDICINE (2008)
Liaisons dangereuses: autophagy, neuronal survival and neurodegeneration
Sharon A. Tooze et al.
CURRENT OPINION IN NEUROBIOLOGY (2008)
The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS
Makoto Urushitani et al.
FASEB JOURNAL (2008)
Huntington's disease: degradation of mutant huntingtin by autophagy
Sovan Sarkar et al.
FEBS JOURNAL (2008)
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
Hideki Nishitoh et al.
GENES & DEVELOPMENT (2008)
Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation
Heidrun Witan et al.
HUMAN MOLECULAR GENETICS (2008)
A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
Eva Teuling et al.
HUMAN MOLECULAR GENETICS (2008)
Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish
Francois Gros-Louis et al.
HUMAN MOLECULAR GENETICS (2008)
Lysosomal proliferation and distal degeneration in motor neurons expressing the G59S mutation in the p150Glued subunit of dynactin
Erica S. Chevalier-Larsen et al.
HUMAN MOLECULAR GENETICS (2008)
VAPB interacts with and modulates the activity of ATF6
Christos Gkogkas et al.
HUMAN MOLECULAR GENETICS (2008)
Activating transcription factor 4
Kurosh Ameri et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2008)
AIP1 is critical in transducing IRE1-mediated endoplasmic reticulum stress response
Dianhong Luo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Structural determinants of the cellular localization and shuttling of TDP-43
Youhna M. Ayala et al.
JOURNAL OF CELL SCIENCE (2008)
ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo
Philipp S. Lange et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2008)
Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells
Yeo Kyoung Oh et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis
Alexander Sarlette et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2008)
Anterior horn cells with abnormal TDP-43 immunoreactivities show fragmentation of the Golgi apparatus in ALS
Yukio Fujita et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2008)
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
John-Paul Upton et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Arimoclomol at dosages up to 300 mg/day is well tolerated and safe in amyotrophic lateral sclerosis
Merit E. Cudkowicz et al.
MUSCLE & NERVE (2008)
Autophagy fights disease through cellular self-digestion
Noboru Mizushima et al.
NATURE (2008)
The BCL-2 protein family: opposing activities that mediate cell death
Richard J. Youle et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
One step at a time: endoplasmic reticulum-associated degradation
Shruthi S. Vembar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
A Golgi fragmentation pathway in neurodegeneration
Saya Nakagomi et al.
NEUROBIOLOGY OF DISEASE (2008)
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
Julie D. Atkin et al.
NEUROBIOLOGY OF DISEASE (2008)
Spinal anterior horn cells in sporadic amyotrophic lateral sclerosis show ribosomal detachment from, and cisternal distention of the rough endoplasmic reticulum
K. Oyanagi et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2008)
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
H. -L. Feng et al.
NEUROSCIENCE (2008)
The endoplasmic reticulum in apoptosis and autophagy: role of the BCL-2 protein family
H. M. Heath-Engel et al.
ONCOGENE (2008)
SOD1 and Amyotrophic Lateral Sclerosis: Mutations and Oligomerization
Lucia Banci et al.
PLOS ONE (2008)
Messenger RNA Oxidation Occurs Early in Disease Pathogenesis and Promotes Motor Neuron Degeneration in ALS
Yueming Chang et al.
PLOS ONE (2008)
Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis
Claudio Hetz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Lithium delays progression of amyotrophic lateral sclerosis
Francesco Fornai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
Bradley J. Turner et al.
PROGRESS IN NEUROBIOLOGY (2008)
Protein aggregation and protein instability govern familial amyotrophic lateral sclerosis patient survival
Qi Wang et al.
PLOS BIOLOGY (2008)
Cysteine 111 affects aggregation and cytotoxicity of mutant Cu,Zn-superoxide dismutase associated with familial amyotrophic lateral sclerosis
Mauro Cozzolino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
A rational mechanism for combination treatment of Huntington's disease using lithium and rapamycin
Sovan Sarkar et al.
HUMAN MOLECULAR GENETICS (2008)
The role of exosomes in the processing of proteins associated with neurodegenerative diseases
Laura J. Vella et al.
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS (2008)
The G59S mutation in p150glued causes dysfunction of dynactin in mice
Chen Lai et al.
JOURNAL OF NEUROSCIENCE (2007)
Deletion of the BH3-only protein puma protects motoneurons from ER stress-induced apoptosis and delays motoneuron loss in ALS mice
Dairin Kieran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Increased ER stress during motor neuron degeneration in a transgenic mouse model of amyotrophic lateral sclerosis
Tetsuya Nagata et al.
NEUROLOGICAL RESEARCH (2007)
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
Ekaterina V. Ilieva et al.
BRAIN (2007)
Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial
Paul H. Gordon et al.
LANCET NEUROLOGY (2007)
Alsin and the molecular pathways of amyotrophic lateral sclerosis
Jayanth Chandran et al.
MOLECULAR NEUROBIOLOGY (2007)
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes
Tom A. Rapoport
NATURE (2007)
Evidence for secretion of Cu,Zn superoxide dismutase via exosomes from a cell model of amyotrophic lateral sclerosis
Catarina Gomes et al.
NEUROSCIENCE LETTERS (2007)
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
Maria Filimonenko et al.
JOURNAL OF CELL BIOLOGY (2007)
Structural characterization of zinc-deficient human superoxide dismutase and implications for ALS
Blaine R. Roberts et al.
JOURNAL OF MOLECULAR BIOLOGY (2007)
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative disease
Christian S. Lobsiger et al.
NATURE NEUROSCIENCE (2007)
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
Yanling Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
ESCRTs and Fab1 regulate distinct steps of autophagy
Tor Erik Rusten et al.
CURRENT BIOLOGY (2007)
Lack of caspase-dependent apoptosis in spinal motor neurons of the wobbler mouse
Paolo Bigini et al.
NEUROSCIENCE LETTERS (2007)
An In Vitro Model for Lewy Body-Like Hyaline Inclusion/Astrocytic Hyaline Inclusion: Induction by ER Stress with an ALS-Linked SOD1 Mutation
Satoru Yamagishi et al.
PLOS ONE (2007)
Two regulatory steps of ER-stress sensor Ire1 involving its cluster formation and interaction with unfolded proteins
Yukio Kimata et al.
JOURNAL OF CELL BIOLOGY (2007)
Prion Pathogenesis is Independent of Caspase-12
Andrew D. Steele et al.
PRION (2007)
Unveiling the roles of autophagy in innate and adaptive immunity
Beth Levine et al.
NATURE REVIEWS IMMUNOLOGY (2007)
Disulfide bond mediates aggregation, toxicity, and ubiquitylation of familial amyotrophic lateral sclerosis-linked mutant SOD1
Jun-ichi Niwa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
Jin-A Lee et al.
CURRENT BIOLOGY (2007)
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
Nobutoshi Morimoto et al.
BRAIN RESEARCH (2007)
Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates
Eva Teuling et al.
JOURNAL OF NEUROSCIENCE (2007)
Messenger RNA oxidation is an early event preceding cell death and causes reduced protein expression
Xiu Shan et al.
FASEB JOURNAL (2007)
A mutation in human VAP-B-MSP domain, present in ALS patients, affects the interaction with other cellular proteins
M. Mitne-Neto et al.
PROTEIN EXPRESSION AND PURIFICATION (2007)
Soluble misfolded subfractions of mutant superoxide dismutase-1s are enriched in spinal cords throughout life in murine ALS models
Per Zetterstrom et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
Clement Y. Chow et al.
NATURE (2007)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis
C. Hetz et al.
CELL DEATH AND DIFFERENTIATION (2007)
ER stress triggers apoptosis by activating BH3-only protein Bim
Hamsa Puthalakath et al.
CELL (2007)
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
Makiko Nagai et al.
NATURE NEUROSCIENCE (2007)
p62 accumulates and enhances aggregate formation in model systems of familial amyotrophic lateral sclerosis
Jozsef Gal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Overexpression of CCS in G93A-SOD1 mice leads to accelerated neurological deficits with severe mitochondrial pathology
Marjatta Son et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis
Jin Hee Shin et al.
MOLECULAR PHARMACOLOGY (2007)
Cerebrospinal fluid from amyotrophic lateral sclerosis patients causes fragmentation of the Golgi apparatus in the neonatal rat spinal cord
Priti Y. Ramamohan et al.
AMYOTROPHIC LATERAL SCLEROSIS (2007)
Fragmentation of the Golgi apparatus: An early apoptotic event independent of the cytoskeleton
Shaeri Mukherjee et al.
TRAFFIC (2007)
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and α-synuclein
Sovan Sarkar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
Makoto Urushitani et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation
Y. Kouroku et al.
CELL DEATH AND DIFFERENTIATION (2007)
Dorfin-CHIP chimeric proteins potently ubiquitylate and degrade familial ALS-related mutant SOD1 proteins and reduce their cellular toxicity
Shinsuke Ishigaki et al.
NEUROBIOLOGY OF DISEASE (2007)
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: Mechanisms of mitochondriopathy and cell death
Lee J. Martin et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2007)
Interaction between familial amyotrophic lateral sclerosis (ALS)-linked SOD1 mutants and the dynein complex
Fujian Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Perk-dependent translational regulation promotes tumor cell adaptation and angiogenesis in response to hypoxic stress
Jaime D. Blais et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies
Hyungjin Kim et al.
NATURE CELL BIOLOGY (2006)
Motor neuron disease in mice expressing the wild type-like D90A mutant superoxide dismutase-1
P. Andreas Jonsson et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2006)
Bcl2a1 serves as a switch in death of motor neurons in amyotrophic lateral sclerosis
C. Crosio et al.
CELL DEATH AND DIFFERENTIATION (2006)
Oxidative stress in ALS: A mechanism of neurodegeneration and a therapeutic target
Sian C. Barber et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
Yuji Mizuno et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)
Gene therapy for ALS: Progress and prospects
Mimoun Azzouz
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
On the relation of oxidative stress to neuroinflammation: Lessons learned from the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
Kenneth Hensley et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Genetics of familial and sporadic amyotrophic lateral sclerosis
Francois Gros-Louis et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
The roles of intracellular protein-degradation pathways in neurodegeneration
David C. Rubinsztein
NATURE (2006)
Degradation of amyotrophic lateral sclerosis-linked mutant Cu,Zn-superoxide dismutase proteins by macroautophagy and the proteasome
Tomohiro Kabuta et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
被撤回的出版物: Induction of the unfolded protein response in familial amyotrophic lateral sclerosis and association of protein-disulfide isomerase with superoxide dismutase 1 (Retracted article. See vol. 292, pg. 12007, 2017)
Julie D. Atkin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8)
Kohsuke Kanekura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
ALS:: A disease of motor neurons and their nonneuronal neighbors
Sverine Boillee et al.
NEURON (2006)
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
N. Parkinson et al.
NEUROLOGY (2006)
Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials
Alberto Ferri et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
Umut Oezcan et al.
SCIENCE (2006)
Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
Thomas W. Gould et al.
JOURNAL OF NEUROSCIENCE (2006)
Antisense oligonucleotide therapy for neurodegenerative disease
Richard A. Smith et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Inter-organelle membrane contact sites: through a glass, darkly
Tim Levine et al.
CURRENT OPINION IN CELL BIOLOGY (2006)
Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response
Julie Hollien et al.
SCIENCE (2006)
Progressive spinal axonal degeneration and slowness in ALS2-deficient mice
Koji Yamanaka et al.
ANNALS OF NEUROLOGY (2006)
Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen
Clare A. Wood-Allum et al.
BRAIN (2006)
Trial of celecoxib in amyotrophic lateral sclerosis
Merit E. Cudkowicz et al.
ANNALS OF NEUROLOGY (2006)
Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities
R. S. Devon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
XIAP decreases caspase-12 cleavage and calpain activity in spinal cord of ALS transgenic mice
Hanna Wootz et al.
EXPERIMENTAL CELL RESEARCH (2006)
S-Nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration
Takashi Uehara et al.
NATURE (2006)
Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria
HX Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Disulfide cross-linked protein represents a significant fraction of ALS-associated Cu, Zn-superoxide dismutase aggregates in spinal cords of model mice
Y Furukawa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis
MR Vargas et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Mitochondrial dysfunction and amyotrophic lateral sclerosis
I Hervias et al.
MUSCLE & NERVE (2006)
Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1α
C Hetz et al.
SCIENCE (2006)
Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice
M Saleh et al.
NATURE (2006)
Spinal cord endoplasmic reticulum stress associated with a microsomal accumulation of mutant superoxide dismutase-1 in an ALS model
H Kikuchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
EDEM3, a soluble EDEM homolog, enhances glycoprotein endoplasmic reticulum-associated degradation and mannose trimming
K Hirao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inositol and IP3 levels regulate autophagy - Biology and therapeutic speculations
Sovan Sarkar et al.
AUTOPHAGY (2006)
Mitochondrial involvement in amyotrophic lateral sclerosis - Trigger or target?
SR Bacman et al.
MOLECULAR NEUROBIOLOGY (2006)
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1α-mediated NF-κB activation and down-regulation of TRAF2 expression
P Hu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Endoplasmic reticulum stress-induced apoptosis - Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
JZ Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Selective vulnerability and pruning of phasic motoneuron axons in motoneuron disease alleviated by CNTF
S Pun et al.
NATURE NEUROSCIENCE (2006)
ER stress and neurodegenerative diseases
D Lindholm et al.
CELL DEATH AND DIFFERENTIATION (2006)
Central role of the scaffold protein tumor necrosis factor receptor- associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis
C Mauro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
S Hadano et al.
HUMAN MOLECULAR GENETICS (2006)
Trehalose reduces aggregate formation and delays pathology in a transgenic mouse model of oculopharyngeal muscular dystrophy
JE Davies et al.
HUMAN MOLECULAR GENETICS (2006)
Molecular biology of amyotrophic lateral sclerosis: insights from genetics
Piera Pasinelli et al.
NATURE REVIEWS NEUROSCIENCE (2006)
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
M Urushitani et al.
NATURE NEUROSCIENCE (2006)
On the mechanism of sensing unfolded protein in the endoplasmic reticulum
JJ Credle et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Golgi apparatus of the motor neurons in patients with amyotrophic lateral sclerosis and in mice models of amyotrophic lateral sclerosis
Y Fujita et al.
NEUROPATHOLOGY (2005)
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
G Bjorkoy et al.
JOURNAL OF CELL BIOLOGY (2005)
Mutation of Vps54 causes motor neuron disease and defective spermiogenesis in the wobbler mouse
T Schmitt-John et al.
NATURE GENETICS (2005)
Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD
C Münch et al.
ANNALS OF NEUROLOGY (2005)
ALS2/Alsin regulates Rac-PAK signaling and neurite outgrowth
EL Tudor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Endoplasmic reticulum stress: cell life and death decisions
CY Xu et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation
AS Vlug et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2005)
Lithium induces autophagy by inhibiting inositol monophosphatase
S Sarkar et al.
JOURNAL OF CELL BIOLOGY (2005)
Endoplasmic reticulum stress response and neurodegeneration
W Paschen et al.
CELL CALCIUM (2005)
Caspase-12 and caspase-4 are not required for caspase-dependent endoplasmic reticulum stress-induced apoptosis
EA Obeng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress
HB Cai et al.
JOURNAL OF NEUROSCIENCE (2005)
The pathobiology of amyotrophic lateral sclerosis: A proteinopathy?
MJ Strong et al.
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2005)
Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
JR Babu et al.
JOURNAL OF NEUROCHEMISTRY (2005)
Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS
J Kirby et al.
BRAIN (2005)
Structural basis of FFAT motif-mediated ER targeting
SE Kaiser et al.
STRUCTURE (2005)
Caspase-resistant golgin-160 by secretory pathway stress disrupts apoptosis induced and ligation of death receptors
RS Maag et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
A mutation in dynein rescues axonal transport defects and extends the life span of ALS mice
D Kieran et al.
JOURNAL OF CELL BIOLOGY (2005)
Caspases-2, -3, and -7 are involved in thapsigargin-induced apoptosis of SH-SY5Y neuroblastoma cells
MK Dahmer
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
Virus-delivered small RNA silencing sustains strength in amyotrophic lateral sclerosis
TM Miller et al.
ANNALS OF NEUROLOGY (2005)
Mutant superoxide dismutase disrupts cytoplasmic dynein in motor neurons
LA Ligon et al.
NEUROREPORT (2005)
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
GS Ralph et al.
NATURE MEDICINE (2005)
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
C Raoul et al.
NATURE MEDICINE (2005)
The disulfide isomerase Grp58 is a protective factor against prion neurotoxicity
C Hetz et al.
JOURNAL OF NEUROSCIENCE (2005)
A selective inhibitor-of eIF2α dephosphorylation protects cells from ER stress
M Boyce et al.
SCIENCE (2005)
Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
BJ Turner et al.
JOURNAL OF NEUROSCIENCE (2005)
Disruption of the structure of the Golgi apparatus and the function of the secretory pathway by mutants G93A and G85R of Cu, Zn superoxide dismutase (SOD1) of familial amyotrophic lateral sclerosis
A Stieber et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2004)
Expression of ubiquitin-binding protein p62 in ubiquitin-immunoreactive intraneuronal inclusions in amyotrophic lateral sclerosis with dementia: analysis of five autopsy cases with broad clinicopathological spectrum
T Nakano et al.
ACTA NEUROPATHOLOGICA (2004)
The biogenesis of multivesicular endosomes
J Gruenberg et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2004)
Caspase-mediated cleavage of syntaxin 5 and giantin accompanies inhibition of secretory traffic during apoptosis
M Lowe et al.
JOURNAL OF CELL SCIENCE (2004)
Regulation of mRNA translation by protein folding in the endoplasmic reticulum
RJ Kaufman
TRENDS IN BIOCHEMICAL SCIENCES (2004)
Oxidative protein folding in eukaryotes: mechanisms and consequences
BP Tu et al.
JOURNAL OF CELL BIOLOGY (2004)
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease
M Tanaka et al.
NATURE MEDICINE (2004)
Cell death: Critical control points
NN Danial et al.
CELL (2004)
Caspase-12 cleavage and increased oxidative stress during motoneuron degeneration in transgenic mouse model of ALS
H Wootz et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Degradation of misfolded proteins prevents ER-derived oxidative stress and cell death
CM Haynes et al.
MOLECULAR CELL (2004)
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
ML Seibenhener et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Nck-dependent activation of extracellular signal-regulated kinase-1 and regulation of cell survival during endoplasmic reticulum stress
DT Nguyên et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS
C Münch et al.
NEUROLOGY (2004)
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak et al.
GENES & DEVELOPMENT (2004)
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
P Pasinelli et al.
NEURON (2004)
CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70
M Urushitani et al.
JOURNAL OF NEUROCHEMISTRY (2004)
A role for astrocytes in motor neuron loss in amyotrophic lateral sclerosis
LH Barbeito et al.
BRAIN RESEARCH REVIEWS (2004)
Mitochondrial proteomic analysis of a cell line model of familial amyotrophic lateral sclerosis
K Fukada et al.
MOLECULAR & CELLULAR PROTEOMICS (2004)
Molecular mechanisms of amyotrophic lateral sclerosis: recent contributions from studies in animal models.
L Dupuis et al.
REVUE NEUROLOGIQUE (2004)
Regulatory roles of JNK in programmed cell death
H Kanda et al.
JOURNAL OF BIOCHEMISTRY (2004)
Life span extension and reduced neuronal death after weekly intraventricular cyclosporin injections in the G93A transgenic mouse model of amyotrophic lateral sclerosis
J Karlsson et al.
JOURNAL OF NEUROSURGERY (2004)
Translocation of bim to the endoplasmic reticulum (ER) mediates ER stress signaling for activation of caspase-12 during ER stress-induced apoptosis
N Morishima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Protein-tyrosine phosphatase 1B potentiates IRE1 signaling during endoplasmic reticulum stress
[Anonymous]
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Transcriptional activation of p62/A170/ZIP during the formation of the aggregates: possible mechanisms and the role in Lewy body formation in Parkinson's disease
K Nakaso et al.
BRAIN RESEARCH (2004)
Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
JD Topp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
AL Nishimura et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
B Ravikumar et al.
NATURE GENETICS (2004)
Mitochondria in Amyotrophic Lateral Sclerosis: A Trigger and a Target
Luc Dupuis et al.
NEURODEGENERATIVE DISEASES (2004)
S-nitrosylation of Parkin regulates ubiquitination and compromises Parkin's protective function
KKK Chung et al.
SCIENCE (2004)
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms
M Saleh et al.
NATURE (2004)
Increased expression of p62 in expanded polyglutamine-expressing cells and its association with polyglutamine inclusions
U Nagaoka et al.
JOURNAL OF NEUROCHEMISTRY (2004)
Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport
CC Hoogenraad et al.
EMBO JOURNAL (2003)
Caspase-12 and endoplasmic reticulum stress mediate neurotoxicity of pathological prion protein
C Hetz et al.
EMBO JOURNAL (2003)
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
AM Clement et al.
SCIENCE (2003)
Gene expression during ER stress-induced apoptosis in neurons:: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway
C Reimertz et al.
JOURNAL OF CELL BIOLOGY (2003)
Death from within: apoptosis and the secretory pathway
RS Maag et al.
CURRENT OPINION IN CELL BIOLOGY (2003)
Proteomic analysis of astrocytic secretion in the mouse -: Comparison with the cerebrospinal fluid proteome
M Lafon-Cazal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins
Y Kimata et al.
MOLECULAR BIOLOGY OF THE CELL (2003)
Mutant SOD1 linked to familial amyotrophic lateral sclerosis, but not wild-type SOD1, induces ER stress in COS7 cells and transgenic mice
S Tobisawa et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
Mechanisms of disease - The chromogranin-secretogranin family.
L Taupenot et al.
NEW ENGLAND JOURNAL OF MEDICINE (2003)
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
HP Harding et al.
MOLECULAR CELL (2003)
Quality control in the endoplasmic reticulum
L Ellgaard et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2003)
Receptor downregulation and multivesicular-body sorting
DJ Katzmann et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)
A caspase cleavage fragment of p115 induces fragmentation of the Golgi apparatus and apoptosis
R Chiu et al.
JOURNAL OF CELL BIOLOGY (2002)
Mitochondrial electron transport chain complex dysfunction in a transgenic mouse model for amyotrophic lateral sclerosis
CW Jung et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity
J Niwa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mutated human SOD1 causes dysfunction of oxidative phosphorylation in mitochondria of transgenic mice
M Mattiazzi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Effect on motor neuron survival in mutant SOD1 (G93A) transgenic mice by Bcl-2 expression using retrograde axonal transport of adenoviral vectors
S Yamashita et al.
NEUROSCIENCE LETTERS (2002)
Tauroursodeoxycholic acid, a bile acid, is neuroprotective in a transgenic model of Huntington's disease
CD Keene et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Nogo provides a molecular marker for diagnosis of amyotrophic lateral sclerosis
L Dupuis et al.
NEUROBIOLOGY OF DISEASE (2002)
Mitochondrial dysfunction in a cell culture model of familial amyotrophic lateral sclerosis
FM Menzies et al.
BRAIN (2002)
Cu/Zn superoxide dismutase (SOD1) mutations associated with familial amyotrophic lateral sclerosis (ALS) affect cellular free radical release in the presence of oxidative stress
MR Cookson et al.
AMYOTROPHIC LATERAL SCLEROSIS AND OTHER MOTOR NEURON DISORDERS (2002)
Disruption of dynein/dynactin inhibits axonal transport in motor neurons causing late-onset progressive degeneration
BH LaMonte et al.
NEURON (2002)
The luminal domain of ATF6 senses endoplasmic reticulum (ER) stress and causes translocation of ATF6 from the ER to the Golgi
X Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Neuroprotection by a bile acid in an acute stroke model in the rat
TMP Rodrigues et al.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)
Mutant Cu, Zn superoxide dismutase that causes motoneuron degeneration is present in mitochondria in the CNS
CMJ Higgins et al.
JOURNAL OF NEUROSCIENCE (2002)
IREI-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response
K Lee et al.
GENES & DEVELOPMENT (2002)
Caspase-mediated cleavage of the stacking protein GRASP65 is required for Golgi fragmentation during apoptosis
JD Lane et al.
JOURNAL OF CELL BIOLOGY (2002)
IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
NATURE (2002)
Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis
P Cassina et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease
M Nagai et al.
JOURNAL OF NEUROSCIENCE (2001)
Subcellular distribution of superoxide dismutases (SOD) in rat liver - Cu,Zn-SOD in mitochondria
A Okado-Matsumoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
Y Yang et al.
NATURE GENETICS (2001)
A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
S Hadano et al.
NATURE GENETICS (2001)
Ubiquitin-binding protein p62 is present in neuronal and glial inclusions in human tauopathies and synucleinopathies
E Kuusisto et al.
NEUROREPORT (2001)
Bcl-2 expression by retrograde transport of adenoviral vectors with Cre-IoxP recombination system in motor neurons of mutant SOD1 transgenic mice
S Yamashita et al.
GENE THERAPY (2001)
Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150Glued stops dynein-dependent membrane motility
JD Lane et al.
JOURNAL OF CELL BIOLOGY (2001)
Medical progress: Amyotrophic lateral sclerosis.
LP Rowland et al.
NEW ENGLAND JOURNAL OF MEDICINE (2001)
Synthetic superoxide dismutase/catalase mimetics reduce oxidative stress and prolong survival in a mouse amyotrophic lateral sclerosis model
CW Jung et al.
NEUROSCIENCE LETTERS (2001)
Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
A Pramatarova et al.
JOURNAL OF NEUROSCIENCE (2001)
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
T Yoneda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Intrathecal cyclosporin prolongs survival of late-stage ALS mice
M Keep et al.
BRAIN RESEARCH (2001)
Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming
J Wolfers et al.
NATURE MEDICINE (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
KD McCullough et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Rho GTPases in growth cone guidance
BJ Dickson
CURRENT OPINION IN NEUROBIOLOGY (2001)
Biochemical basis of oxidative protein folding in the endoplasmic reticulum
BP Tu et al.
SCIENCE (2000)
Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1G93A mutation of familial amyotrophic lateral sclerosis
A Stieber et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2000)
Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response
A Bertolotti et al.
NATURE CELL BIOLOGY (2000)
Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding bcl-2
M Azzouz et al.
HUMAN MOLECULAR GENETICS (2000)
Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis
M Mancini et al.
JOURNAL OF CELL BIOLOGY (2000)
The neuronal Golgi apparatus is fragmented in transgenic mice expressing a mutant human SOD1, but not in mice expressing the human NF-H gene
A Stieber et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2000)
Mouse VAP33 is associated with the endoplasmic reticulum and microtubules
PA Skehel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
F Urano et al.
SCIENCE (2000)
分享论文
