期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 13, 期 12, 页码 1899-1910出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2010.3464
关键词
-
资金
- Swiss National Science Foundation [3232B-111352, 3200B-111353]
- Swiss Heart Foundation
- SwissLife Jubilaumsstiftung
- Mach-Gaensslen Foundation Switzerland
- Kardiovaskulare Stiftung Basel
The totality of functional cardiomyocytes and an intact cardiac progenitor cell pool are key players in the myocardial cell homeostasis. Perturbation of either one may compromise the structural and functional integrity of the heart and lead to heart failure. Reactive oxygen/nitrogen species (ROS/RNS) are important regulators of cardiomyocyte viability; more recently, the interrelation between ROS and progenitor cell behavior and fate has moved into the spotlight. Increasing evidence suggests not only that ROS participate in the regulation of cardiac progenitor cell survival but also that they likewise affect their functional properties in terms of self-proliferation and differentiation. The apparent dichotomy of ROS/RNS effects with their adaptive and regulatory character on the one hand and their maladaptive and damaging features on the other pose a great challenge in view of the therapeutic exploitation of their role in the regulation of the myocardial cell homeostasis. In this article, mechanisms and potential significance of ROS/RNS action in the regulation of the myocardial cell homeostasis, in particular with respect to the preservation of viable cardiomyocytes and the maintenance of a functional cardiac progenitor cell pool, will be discussed. Antioxid. Redox Signal. 13, 1899-1910.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据