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James R. Berenson et al.
CLINICAL CANCER RESEARCH (2007)
Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
Baskaran Govindarajan et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
Opinion - Why is cancer drug discovery so difficult?
Alexander Kamb et al.
NATURE REVIEWS DRUG DISCOVERY (2007)
Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death
Shoichiro Asayama et al.
JOURNAL OF INORGANIC BIOCHEMISTRY (2007)
Reactive oxygen species: A breath of life or death?
John P. Fruehauf et al.
CLINICAL CANCER RESEARCH (2007)
Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
Anna Berkenblit et al.
CLINICAL CANCER RESEARCH (2007)
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth
Sebastien Bonnet et al.
CANCER CELL (2007)
Acute apoptosis by cisplatin requires induction of reactive oxygen species but is not associated with damage to nuclear DNA
Maria Berndtsson et al.
INTERNATIONAL JOURNAL OF CANCER (2007)
Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer
T. E. Roche et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2007)
Willmar Schwabe Award 2006: Antiplasmodial and antitumor activity of arternisinin - From bench to bedside
Thomas Efferth
PLANTA MEDICA (2007)
2-Deoxy-D-glucose combined with cisplatin, enhances cytotoxicity via metabolic oxidative stress in human head and neck cancer cells
Andreart L. Simons et al.
CANCER RESEARCH (2007)
Drug-mediated targeted disruption of multiple protein activities through functional inhibition of the Hsp90 chaperone complex
Dimitrios J. Stravopodis et al.
CURRENT MEDICINAL CHEMISTRY (2007)
Glycolysis in cancer: A potential target for therapy
Robert A. Gatenby et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2007)
Dimethylfumarate impairs melanoma growth and metastasis
Robert Loewe et al.
CANCER RESEARCH (2006)
Pentose phosphate cycle oxidative and nonoxidative balance:: A new vulnerable target for overcoming drug resistance in cancer
Antonio Ramos-Montoya et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
Mitochondrial production of reactive oxygen species mediate dicumarol-induced cytotoxicity in cancer cells
Juan Du et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer
Li Hua Wang et al.
CANCER CELL (2006)
Motexafin gadolinium: A novel redox active drug for cancer therapy
Darren Magda et al.
SEMINARS IN CANCER BIOLOGY (2006)
Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing hypoxic tumor cells
Theodore J. Lampidis et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Bioenergetics and the formation of mitochondrial reactive oxygen species
Vera Adam-Vizi et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2006)
Preclinical antitumor activity, pharmacokinetics and pharmacodynamics of imexon in mice
Alan Pourpak et al.
ANTI-CANCER DRUGS (2006)
Recruitment of HIF-1α and HIF-2α to common target genes is differentially regulated in neuroblastoma:: HIF-2α promotes an aggressive phenotype
Linda Holmquist-Mengelbier et al.
CANCER CELL (2006)
Disulfiram, a clinically used anti-alcoholism drug and copper-binding agent, induces apoptotic cell death in breast cancer cultures and xenografts via inhibition of the proteasome activity
Di Chen et al.
CANCER RESEARCH (2006)
Protein disulfide isomerase expression is related to the invasive properties of malignant glioma
Dorota Goplen et al.
CANCER RESEARCH (2006)
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics
Megan Whitnall et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Glutathione peroxidases and redox-regulated transcription factors
Regina Brigelius-Flohe
BIOLOGICAL CHEMISTRY (2006)
Hypoxia: Importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy
James L. Tatum et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2006)
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
Anju Singh et al.
PLOS MEDICINE (2006)
Pharmacologic blockade of angiopoietin-2 is efficacious against model hemangiomas in mice
Betsy N. Perry et al.
JOURNAL OF INVESTIGATIVE DERMATOLOGY (2006)
The bioreduction of a series of benzoquinone ansamycins by NAD(P)H: quinone oxidoreductase 1 to more potent heat shock protein 90 inhibitors, the hydroquinone ansamycins
Wenchang Guo et al.
MOLECULAR PHARMACOLOGY (2006)
Oxidative inhibition of receptor-type protein-tyrosine phosphatase κ by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes
Yiru Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant
Nuri Gueven et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Oxidative stress by ascorbate/menadione association kills K562 human chronic myelogenous leukaemia cells and inhibits its tumour growth in nude mice
Julien Verrax et al.
BIOCHEMICAL PHARMACOLOGY (2006)
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by β-phenylethyl isothiocyanate
Dunyaporn Trachootham et al.
CANCER CELL (2006)
Use of three-dimensional tissue cultures to model extravascular transport and predict in vivo activity of hypoxia-targeted anticancer drugs
Kevin O. Hicks et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
Copper binding by tetrathiomolybdate attenuates angiogenesis and tumor cell proliferation through the inhibition of superoxide dismutase 1
Jose C. Juarez et al.
CLINICAL CANCER RESEARCH (2006)
Glycolysis inhibition for anticancer treatment
H. Pelicano et al.
ONCOGENE (2006)
Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
S. P. Mathupala et al.
ONCOGENE (2006)
Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth
Christine J. Weydert et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
Karim Bensaad et al.
CELL (2006)
BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance
Mateusz Koptyra et al.
BLOOD (2006)
Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo
Jerome Alexandre et al.
INTERNATIONAL JOURNAL OF CANCER (2006)
5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl] indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo
Donna L. Dehn et al.
MOLECULAR CANCER THERAPEUTICS (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
Inhibition of glutathione synthesis overcomes Bcl-2-mediated topoisomerase inhibitor resistance and induces nonapoptotic cell death via mitochondrial-independent pathway
Akira Yoshida et al.
CANCER RESEARCH (2006)
PM-20, a novel inhibitor of Cdc25A, induces extracellular signal-regulated kinase 1/2 phosphorylation and inhibits hepatocellular carcinoma growth in vitro and in vivo
Siddhartha Kar et al.
MOLECULAR CANCER THERAPEUTICS (2006)
The crystal structure of NAD(P)H quinone oxidoreductase 1 in complex with its potent inhibitor dicoumarol
Gad Asher et al.
BIOCHEMISTRY (2006)
Thioredoxin reductase as a novel molecular target for cancer therapy
Phuongmai Nguyen et al.
CANCER LETTERS (2006)
Inhibition of breast cancer cell growth and induction of cell death by 1,1-bis(3′-indolyl)methane (DIM) and 5,5′-dibromoDIM
Kathy Vanderlaag et al.
CANCER LETTERS (2006)
c-Jun NH2-terminal kinase signaling axis regulates diallyl trisulfide-induced generation of reactive oxygen species and cell cycle arrest in human prostate cancer cells
Jedrzej Antosiewicz et al.
CANCER RESEARCH (2006)
Modeling of Cdc25B dual specifity protein phosphatase inhibitors: Docking of ligands and enzymatic inhibition mechanism
Antonio Lavecchia et al.
CHEMMEDCHEM (2006)
Glucose withdrawal induces oxidative stress followed by apoptosis in glioblastoma cells but not in normal human astrocytes
Nannette Jelluma et al.
MOLECULAR CANCER RESEARCH (2006)
3,3′-diindolylmethane is a novel mitochondrial H+-ATP synthase inhibitor that can induce p21Cip1/Waf1 expression by induction of oxidative stress in human breast cancer cells
Yixuan Gong et al.
CANCER RESEARCH (2006)
Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase
SI Hashemy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Phase I and pharmacokinetic study of the novel redox-active agent, motexafin gadolinium, with concurrent radiation therapy in patients with locally advanced pancreatic or biliary cancers
RK Ramanathan et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2006)
Multicenter randomized phase III study of the cardioprotective effect of dexrazoxane (Cardioxane®) in advanced/metastatic breast cancer patients treated with anthracycline-based chemotherapy
M Marty et al.
ANNALS OF ONCOLOGY (2006)
Molecular pharmacology and pharmacogenomics of artemisinin and its derivatives in cancer cells
T Efferth
CURRENT DRUG TARGETS (2006)
Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors thioredoxin reductase
G Powis et al.
MOLECULAR CANCER THERAPEUTICS (2006)
Catalase reverses tumorigenicity in a malignant cell line by an epidermal growth factor receptor pathway
JS Finch et al.
FREE RADICAL BIOLOGY AND MEDICINE (2006)
Improvement of the therapeutic index of anticancer drugs by the superoxide dismutase mimic mangafodipir
J Alexandre et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2006)
PABA/NO as an anticancer lead: Analogue synthesis, structure revision, solution chemistry, reactivity toward glutathione, and in vitro activity
JE Saavedra et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
The antitumor thioredoxin-1 inhibitor PX-12 (1-methylpropyl 2-imidazolyl disulfide) decreases thioredoxin-1 and VEGF levels in cancer patient plasma
AF Baker et al.
JOURNAL OF LABORATORY AND CLINICAL MEDICINE (2006)
Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5
H Kim et al.
CANCER RESEARCH (2006)
Oral artemisinin prevents and delays the development of 7,12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in the rat
H Lai et al.
CANCER LETTERS (2006)
Bcl-2 and Mn-SOD antisense oligodeoxynucleotides and a glutamine-enriched diet facilitate elimination of highly resistant B16 melanoma cells by tumor necrosis factor-α and chemotherapy
M Benlloch et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The redox regulation of thiol dependent signaling pathways in cancer
Gregory I. Giles
CURRENT PHARMACEUTICAL DESIGN (2006)
A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms
Claus Jacob
NATURAL PRODUCT REPORTS (2006)
Fatty acid oxidation is a dominant bioenergetic pathway in prostate cancer
Y. Liu
PROSTATE CANCER AND PROSTATIC DISEASES (2006)
Endogenous UVA-photosensitizers: mediators of skin photodamage and novel targets for skin photoprotection
GT Wondrak et al.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2006)
The redox regulation of PI 3-kinase-dependent signaling
Nick R. Leslie
ANTIOXIDANTS & REDOX SIGNALING (2006)
Mechanistic basis for therapeutic targeting of the mitochondrial F1F0-ATPase
Kathryn M. Johnson et al.
ACS CHEMICAL BIOLOGY (2006)
Diallyl trisulfide suppresses the proliferation and induces apoptosis of human colon cancer cells through oxidative modification of β-tubulin
T Hosono et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Synergistic effect of targeting mTOR by rapamycin and depleting ATP by inhibition of glycolysis in lymphoma and leukemia cells
RH Xu et al.
LEUKEMIA (2005)
Alterations in the expression of the apurinic/apyrimidinic endonuclease-1/redox factor-1 (APE/Ref-1) in human melanoma and identification of the therapeutic potential of resveratrol as an APE/Ref-1 inhibitor
S Yang et al.
MOLECULAR CANCER THERAPEUTICS (2005)
The antioxidant function of the p53 tumor suppressor
AA Sablina et al.
NATURE MEDICINE (2005)
Methylene blue is more toxic to erythroleukemic cells than to normal peripheral blood mononuclear cells: a possible use in chemotherapy
C Kirszberg et al.
CANCER CHEMOTHERAPY AND PHARMACOLOGY (2005)
Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane
F Hong et al.
CHEMICAL RESEARCH IN TOXICOLOGY (2005)
Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo
GL Disbrow et al.
CANCER RESEARCH (2005)
Mechanisms of therapy-related carcinogenesis
JM Allan et al.
NATURE REVIEWS CANCER (2005)
Population aging and cancer: A cross-national concern
R Yancik
CANCER JOURNAL (2005)
Mitochondrial tumour suppressors: A genetic and biochemical update
E Gottlieb et al.
NATURE REVIEWS CANCER (2005)
Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues
Q Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Resistance to paclitaxel is proportional to cellular total antioxidant capacity
B Ramanathan et al.
CANCER RESEARCH (2005)
Generation of reactive oxygen species by a persultide (BnSSH)
T Chatterji et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2005)
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor KB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway
DR Siwak et al.
CANCER (2005)
Desferal inhibits breast tumor growth and does not interfere with the tumoricidal activity of doxorubicin
EM Hoke et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
Activation of c-Jun-N-terminal kinase is required for apoptosis triggered by glutathione disulfide in neuroblastoma cells
G Filomeni et al.
FREE RADICAL BIOLOGY AND MEDICINE (2005)
Regulation of the cell cycle in response to inhibition of mitochondrial generated energy
A Gemin et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Blocking platelet-derived growth factor-D/platelet-derived growth factor receptor β signaling inhibits human renal cell carcinoma progression in an orthotopic mouse model
L Xu et al.
CANCER RESEARCH (2005)
Thioredoxin reductase is irreversibly modified by curcumin - A novel molecular mechanism for its anticancer activity
JG Fang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
PKC sulfhydryl targeting by disulfiram produces divergent isozymic regulatory responses that accord with the cancer preventive activity of the thiuram disulfide
F Chu et al.
ANTIOXIDANTS & REDOX SIGNALING (2005)
1,2-bis(methylsulfonyl)-1-(2-chloroethyl)-2-[[1-(4-nitrophenyl)ethoxy]carbonyl]hydrazine: An anticancer agent targeting hypoxic cells
HA Seow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The sesquiterpene lactone parthenolide in combination with docetaxel reduces metastasis and improves survival in a xenograft model of breast cancer
CJ Sweeney et al.
MOLECULAR CANCER THERAPEUTICS (2005)
Elucidation of thioredoxin as a molecular target for antitumor quinols
TD Bradshaw et al.
CANCER RESEARCH (2005)
Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines
D Magda et al.
CANCER RESEARCH (2005)
A novel benzodiazepine selectively inhibits keratinocyte proliferation and reduces retinoid-induced epidermal hyperplasia in organ-cultured human skin
J Varani et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Identification and validation of the mitochondrial F1F0-ATPase as the molecular target of the immunomodulatory benzodiazepine Bz-423
KM Johnson et al.
CHEMISTRY & BIOLOGY (2005)
Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice
S Suy et al.
CANCER (2005)
Induction of apoptosis by curcumin and its implications for cancer therapy
D Karunagaran et al.
CURRENT CANCER DRUG TARGETS (2005)
EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanism
BK Adams et al.
ANTI-CANCER DRUGS (2005)
Optimization of 6,7-disubstituted-4-(arylamino)quinoline-3-carbonitriles as orally active, irreversible inhibitors of human epidermal growth factor receptor-2 kinase activity
HR Tsou et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
Mitochondrial O2-• and H2O2 mediate glucose deprivation-induced cytotoxicity and oxidative stress in human cancer cells
IM Ahmad et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mechanistic perspectives for 1,2,4-trioxanes in anti-cancer therapy
T Efferth
DRUG RESISTANCE UPDATES (2005)
Quinols as novel therapeutic agents. 2. 4-(1-arylsulfonylindol-2-yl)-4-hydroxycyclohexa-2,5-dien-1-ones and related agents as potent and selective antitumor agents
JM Berry et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
The concept of synthetic lethality in the context of anticancer therapy
WG Kaelin
NATURE REVIEWS CANCER (2005)
Multifunctional redox catalysts as selective enhancers of oxidative stress
FH Fry et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
Isolation of a small molecule inhibitor of DNA base excision repair
S Madhusudan et al.
NUCLEIC ACIDS RESEARCH (2005)
Tumor cell responses to a novel glutathione S-transferase-activated nitric oxide-releasing prodrug
VJ Findlay et al.
MOLECULAR PHARMACOLOGY (2004)
Ascorbic acid restores sensitivity to imatinib via suppression of Nrf2-dependent gene expression in the imatinib-resistant cell line
T Tarumoto et al.
EXPERIMENTAL HEMATOLOGY (2004)
Enhancement of chemotherapeutic response of tumor cells by a heme oxygenase inhibitor, pegylated zinc protoporphyrin
J Fang et al.
INTERNATIONAL JOURNAL OF CANCER (2004)
Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
YH Zheng et al.
ONCOGENE (2004)
Research advances in the use of tetrapyrrolic photosensitizers for photodynamic therapy
ES Nyman et al.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2004)
Thioredoxin-1 binds to the C2 domain of PTEN inhibiting PTEN's lipid phosphatase activity and membrane binding: a mechanism for the functional loss of PTEN's tumor suppressor activity
EJ Meuillet et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Effects of gemcitabine on APE/ref-1 endonuclease activity in pancreatic cancer cells, and the therapeutic potential of antisense oligonucleotides
JP Lau et al.
BRITISH JOURNAL OF CANCER (2004)
Reactive oxygen species produced by NAD(P)H oxidase inhibit apoptosis in pancreatic cancer cells
EC Vaquero et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Disulfiram facilitates intracellular Cu uptake and induces apoptosis in human melanoma cells
DZ Cen et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate
R Dell'Eva et al.
BIOCHEMICAL PHARMACOLOGY (2004)
DT-diaphorase: a target for new anticancer drugs
S Danson et al.
CANCER TREATMENT REVIEWS (2004)
Synthetic peroxides as antimalarials
YQ Tang et al.
MEDICINAL RESEARCH REVIEWS (2004)
Effective treatment of advanced solid tumors by the combination of arsenic trioxide and L-buthionine-sulfoximine
H Maeda et al.
CELL DEATH AND DIFFERENTIATION (2004)
Treatment of pancreatic cancer cells with Dicumarol induces cytotoxicity and oxidative stress
A Lewis et al.
CLINICAL CANCER RESEARCH (2004)
Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor
LH Wang et al.
NATURE MEDICINE (2004)
Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP
YH Ko et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Chemical basis for the biological activity of imexon and related cyanoaziridines
BS Iyengar et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
G Maschek et al.
CANCER RESEARCH (2004)
Directed biosynthesis of fluorinated pseurotin A, synerazol and gliotoxin
Y Igarashi et al.
JOURNAL OF ANTIBIOTICS (2004)
Proteasome inhibitor PS-341 induces a apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells
A Fribley et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Crystal structure of γ-glutamylcysteine synthetase:: Insights into the mechanism of catalysis by a key enzyme for glutathione homeostasis
T Hibi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation
J Mitsushita et al.
CANCER RESEARCH (2004)
NAD(P)H:quinone oxidoreductase 1:: Role as a superoxide scavenger
D Siegel et al.
MOLECULAR PHARMACOLOGY (2004)
Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling
R Clarke et al.
ONCOGENE (2003)
Redox regulation of PI 3-kinase signalling via inactivation of PTEN
NR Leslie et al.
EMBO JOURNAL (2003)
Superoxide dismutase 1 knock-down induces senescence in human fibroblasts
G Blander et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Inhibition of mitochondrial respiration - A novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism
H Pelicano et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
A nonpeptidyl mimic of superoxide dismutase, M40403, inhibits dose-limiting hypotension associated with interleukin-2 and increases its antitumor effects
WE Samlowski et al.
NATURE MEDICINE (2003)
Small molecules that mimic the thiol-triggered alkylating properties seen in the natural product leinamycin
T Chatterji et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2003)
Gold compound auranofin inhibits IκB kinase (IKK) by modifying Cys-179 of IKKβ subunit
KI Jeon et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2003)
Antitumor effect of the cinnamaldehyde derivative CB403 through the arrest of cell cycle progression in the G2/M phase
HW Jeong et al.
BIOCHEMICAL PHARMACOLOGY (2003)
Phase I trial of high dose paracetamol and carmustine in patients with metastatic melanoma
JD Wolchok et al.
MELANOMA RESEARCH (2003)
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
S Dolma et al.
CANCER CELL (2003)
Chemogenomic identification of Ref-l/AP-1 as a therapeutic target for asthma
C Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
In vivo antiviral activity of novel human immunodeficiency virus type 1 nucleocapsid p7 zinc finger inhibitors in a transgenic murine model
ML Schito et al.
AIDS RESEARCH AND HUMAN RETROVIRUSES (2003)
Redox catalysts as sensitisers towards oxidative stress
NM Giles et al.
FEBS LETTERS (2003)
Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2)
A Wissner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2003)
Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 mitogen-activated protein kinase pathway
G Filomeni et al.
FASEB JOURNAL (2002)
Paradoxical effects of metalloporphyrins on doxorubicin-induced apoptosis: Scavenging of reactive oxygen species versus induction of heme oxygenase-1
EA Konorev et al.
FREE RADICAL BIOLOGY AND MEDICINE (2002)
Cysteine-modifying agents: A possible approach for effective anticancer and antiviral drugs
A Casini et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2002)
Salen-manganese complexes as catalytic scavengers of hydrogen peroxide and cytoprotective agents: structure-activity relationship studies
SR Doctrow et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
Influx of calcium through a redox-sensitive plasma membrane channel in thymocytes causes early necrotic cell death induced by the epipolythiodioxopiperazine toxins
AM Hurne et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Vitamin E succinate inhibits colon cancer liver metastases
KT Barnett et al.
JOURNAL OF SURGICAL RESEARCH (2002)
The iron metabolism of neoplastic cells: alterations that facilitate proliferation?
JC Kwok et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2002)
Characterization of a mechanism-based inhibitor of NAD(P)H: Quinone oxidoreductase 1 by biochemical, X-ray crystallographic, and mass spectrometric approaches
SL Winski et al.
BIOCHEMISTRY (2001)
Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53
JA Bush et al.
EXPERIMENTAL CELL RESEARCH (2001)
Cysteine 38 in p65/NF-κB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
AJ García-Piñeres et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
On the origin of cytotoxicity of the natural product varacin. A novel example of a pentathiepin reaction that provides evidence for a triatomic sulfur intermediate
A Greer
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2001)
2-Methoxyestradiol does not inhibit superoxide dismutase
R Kachadourian et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2001)
Oxidation of zinc finger transcription factors: Physiological consequences
KA Webster et al.
ANTIOXIDANTS & REDOX SIGNALING (2001)
The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IκB kinase
BHB Kwok et al.
CHEMISTRY & BIOLOGY (2001)
Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells
JM Grad et al.
BLOOD (2001)
Electron transfer and oxidative stress as key factors in the design of drugs selectively active in hypoxia
P Wardman
CURRENT MEDICINAL CHEMISTRY (2001)
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
FQ Schafer et al.
FREE RADICAL BIOLOGY AND MEDICINE (2001)
Redox regulation in human melanocytes and melanoma
FL Meyskens et al.
PIGMENT CELL RESEARCH (2001)
Induction of mitochondrial changes in myeloma cells by imexon
K Dvorakova et al.
BLOOD (2001)
Respiratory chain-generated oxidative stress following treatment of leukemic blasts with DNA-damaging agents
NA Pham et al.
EXPERIMENTAL CELL RESEARCH (2001)
Inactivation of the human papillomavirus-16 E6 oncoprotein by organic disulfides
W Beerheide et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2000)
Superoxide dismutase as a target for the selective killing of cancer cells
P Huang et al.
NATURE (2000)
Induction of oxidative stress and apoptosis in myeloma cells by the aziridine-containing agent imexon
K Dvorakova et al.
BIOCHEMICAL PHARMACOLOGY (2000)
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