期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 11, 期 9, 页码 2341-2352出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2009.2705
关键词
-
资金
- Kidney Foundation of Canada, Canadian Diabetes Association
- Canadian Institutes of Health Research
- St. Joseph's Hospital Foundation
The accumulation of unfolded proteins in the endoplasmic reticulum ( ER), leading to ER stress, is caused by a wide range of physiologic and pathologic conditions. Cells respond to ER stress by activating a series of integrative stress pathways termed the unfolded protein response (UPR). This either may be adaptive and promote cell survival, or if the ER stress is chronic or excessive, may lead to cell death. The role of ER stress in the pathophysiology of both acute and chronic kidney diseases has been gaining increasing interest. This review highlights the current knowledge of ER stress in renal disease, with emphasis on more recent advances. Potential therapeutic options targeting ER stress are discussed. Antioxid. Redox Signal. 11, 2341-2352.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据