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CANCER RESEARCH (2008)
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Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells
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MOLECULAR CANCER RESEARCH (2008)
Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium
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A molecular chaperone inducer protects neurons from ER stress
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CELL DEATH AND DIFFERENTIATION (2008)
GRP78 and cripto form a complex at the cell surface and collaborate to inhibit transforming growth factor beta signaling and enhance cell growth
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MOLECULAR AND CELLULAR BIOLOGY (2008)
Altered quality control in the endoplasmic reticulum causes cortical dysplasia in knock-in mice expressing a mutant BiP
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MOLECULAR AND CELLULAR BIOLOGY (2008)
The unfolded protein response regulator GRP78/BiP as a novel target for increasing chemosensitivity in malignant gliomas
Peter Pyrko et al.
CANCER RESEARCH (2007)
Glucose-regulated protein GRP78 is up-regulated in prostate cancer and correlates with recurrence and survival
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Aberrant quality control in the endoplasmic reticulum impairs the biosynthesis of pulmonary surfactant in mice expressing mutant BiP
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CELL DEATH AND DIFFERENTIATION (2007)
ER chaperones in mammalian development and human diseases
Min Ni et al.
FEBS LETTERS (2007)
GRP78 induction in cancer: Therapeutic and prognostic implications
Amy S. Lee
CANCER RESEARCH (2007)
GRP78/BiP inhibits endoplasmic reticulum BIK and protects human breast cancer cells against estrogen starvation-induced apoptosis
Yong Fu et al.
CANCER RESEARCH (2007)
Autophagy is activated for cell survival after endoplasmic reticulum stress
Maiko Ogata et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
D. Thomas Rutkowski et al.
PLOS BIOLOGY (2006)
Expression of stress response protein Grp78 is associated with the development of castration-resistant prostate cancer
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CLINICAL CANCER RESEARCH (2006)
The nucleotide exchange factor activity of Grp 170 may explain the non-lethal phenotype of loss of Sil1 function in man and mouse
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GRP78 as a novel predictor of responsiveness to chemotherapy in breast cancer
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CANCER RESEARCH (2006)
Targeting heat shock proteins on cancer cells: Selection, characterization, and cell-penetrating properties of a peptidic GRP78 ligand
Youngsoo Kim et al.
BIOCHEMISTRY (2006)
GRP78/BiP is required for cell proliferation and protecting the inner cell mass from apoptosis during early mouse embryonic development
Shengzhan Luo et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Glucose regulated proteins in cancer progression, drug resistance and immunotherapy
Yong Fu et al.
CANCER BIOLOGY & THERAPY (2006)
Activation and cross-talk between Akt, NF-κB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78
UK Misra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Endoplasmic reticulum stress-induced apoptosis - Multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
JZ Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
From acute ER stress to physiological roles of the Unfolded Protein Response
J Wu et al.
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Stress induction of GRP78/BiP and its role in cancer
JZ Li et al.
CURRENT MOLECULAR MEDICINE (2006)
ER stress, hypoxia tolerance and tumor progression
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Mutations in SIL1 cause Marinesco-Sjogren syndrome, a cerebellar ataxia with cataract and myopathy
J Senderek et al.
NATURE GENETICS (2005)
The gene disrupted in Marinesco-Sjogren syndrome encodes SIL1, an HSPA5 cochaperone
AK Anttonen et al.
NATURE GENETICS (2005)
Protein accumulation and neurodegeneration in the woozy mutant mouse is caused by disruption of SIL1, a cochaperone of BiP
LH Zhao et al.
NATURE GENETICS (2005)
Regulation of tissue factor-mediated initiation of the coagulation cascade by cell surface Grp78
G Bhattacharjee et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2005)
Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
H Uramoto et al.
LUNG CANCER (2005)
Vascular targeting and antiangiogenesis agents induce drug resistance effector GRP78 within the tumor microenvironment
DZ Dong et al.
CANCER RESEARCH (2005)
Kringle 5 of human plasminogen induces apoptosis of endothelial and tumor cells through surface-expressed glucose-regulated protein 78
DJ Davidson et al.
CANCER RESEARCH (2005)
The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress
AS Lee
METHODS (2005)
Effect on tumor cells of blocking survival response to glucose deprivation
HR Park et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2004)
Cell surface expression of the stress response chaperone GRP78 enables tumor targeting by circulating ligands
MA Arap et al.
CANCER CELL (2004)
A novel receptor function for the heat shock protein Grp78:: silencing of Grp78 gene expression attenuates α2M-induced signalling
UK Misra et al.
CELLULAR SIGNALLING (2004)
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
SJ Marciniak et al.
GENES & DEVELOPMENT (2004)
Misfolded proteins, endoplasmic reticulum stress and neurodegeneration
RV Rao et al.
CURRENT OPINION IN CELL BIOLOGY (2004)
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
PD Lu et al.
JOURNAL OF CELL BIOLOGY (2004)
A trip to the ER: coping with stress
DT Rutkowski et al.
TRENDS IN CELL BIOLOGY (2004)
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
SY Wang et al.
CANCER CELL (2003)
Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis
WX Zong et al.
JOURNAL OF CELL BIOLOGY (2003)
Endoplasmic reticulum chaperone protein GRP78 protects cells from apoptosis induced by topoisomerase inhibitors - Role of ATP binding site in suppression of caspase-7 activation
RK Reddy et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis
M Shuda et al.
JOURNAL OF HEPATOLOGY (2003)
BAX and BAK regulation of endoplasmic reticulum Ca2+:: A control point for apoptosis
L Scorrano et al.
SCIENCE (2003)
Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function
BK Shin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
XBP-1 regulates a subset of endoplasmic reticulum resident chaperone genes in the unfolded protein response
AH Lee et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
BAP, a mammalian BiP-associated protein, is a nucleotide exchange factor that regulates the ATPase activity of BiP
KT Chung et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The role of Grp 78 in α2-macroglobulin-induced signal transduction -: Evidence from RNA interference that the low density lipoprotein receptor-related protein is associated with, but not necessary for, Grp 78-mediated signal transduction
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Coupling endoplasmic reticulum stress to the cell death program - An Apaf-1-independent intrinsic pathway
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
H Nishitoh et al.
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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA
M Calfon et al.
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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of parkin
Y Imai et al.
CELL (2001)
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
T Yoneda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Gadd153 sensitizes cells to endoplasmic reticulum stress by down-regulating Bc12 and perturbing the cellular redox state
KD McCullough et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs
J Ye et al.
MOLECULAR CELL (2000)
Regulated translation initiation controls stress-induced gene expression in mammalian cells
HP Harding et al.
MOLECULAR CELL (2000)
Cross-talk between two cysteine protease families: Activation of caspase-12 by calpain in apoptosis
T Nakagawa et al.
JOURNAL OF CELL BIOLOGY (2000)
ATF6 as a transcription activator of the endoplasmic reticulum stress element: Thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1
MQ Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β
T Nakagawa et al.
NATURE (2000)
Overexpression of the glucose-regulated stress gene GRP78 in malignant but not benign human breast lesions
PM Fernandez et al.
BREAST CANCER RESEARCH AND TREATMENT (2000)
ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response
H Yoshida et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)