期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 11, 期 7, 页码 1699-1709出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2008.2408
关键词
-
资金
- Netherlands Heart Foundation [2001T038]
Shear stress is well known to be a key factor in the regulation of small-artery tone and structure. Although nitric oxide is a major endothelium-derived factor involved in short-and long-term regulation of vascular caliber, it is clear that other mechanisms also can be involved. This review discusses the evidence for endothelium-derived reactive oxygen species (ROS) as mediators for shear-dependent arterial tone and remodeling. The work focuses on resistance vessels, because their caliber determines local perfusion. However, work on large vessels is included where needed. Attention is given to the shear-stress levels and profiles that exist in the arterial system and the differential effects of steady and oscillating shear on NO and ROS production. We furthermore address the relation between microvascular tone and remodeling and the effect of ROS and inflammation on the activity of remodeling enzymes such as matrix metalloproteinases and transglutaminases. We conclude that future work should address the role of H2O2 as an endothelium-derived factor mediating tone and influencing structure of small arteries over the long term. Antioxid. Redox Signal. 11, 1699-1709.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据