相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
Jeehye Park et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
Yongsung Kim et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
Complex I deficiency in Parkinson's disease frontal cortex
W. Davis Parker et al.
BRAIN RESEARCH (2008)
Functions and effects of creatine in the central nervous system
Robert H. Andres et al.
BRAIN RESEARCH BULLETIN (2008)
Mitochondrial association of alpha-synuclein causes oxidative stress
M. S. Parihar et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Rhomboid-7 and HtrA2/Omi act in a common pathway with the Parkinson's disease factors Pink1 and Parkin
Alexander J. Whitworth et al.
DISEASE MODELS & MECHANISMS (2008)
Kynurenic acid attenuates MPP+-induced dopaminergic neuronal cell death via a Bax-mediated mitochondrial pathway
Do Yeon Lee et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2008)
Sequencing analysis of OMI/HTRA2 shows previously reported pathogenic mutations in neurologically normal controls
Javier Simon-Sanchez et al.
HUMAN MOLECULAR GENETICS (2008)
Mitochondrial import and accumulation of α-synuclein impair complex I in human dopaminergic neuronal cultures and Parkinson disease brain
Latha Devi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Functional mitochondria are required for α-synuclein toxicity in aging yeast
Sabrina Buettner et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
Alison Wood-Kaczmar et al.
PLOS ONE (2008)
Genetic variation of Omi/HtrA2 and Parkinson's disease
Owen A. Ross et al.
PARKINSONISM & RELATED DISORDERS (2008)
Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP
M. Emdadul Haque et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
Clement A. Gautier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The PINK1/Parkin pathway regulates mitochondrial morphology
Angela C. Poole et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
Hansong Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1
Andreas Weihofen et al.
HUMAN MOLECULAR GENETICS (2008)
Behavioral and histopathological consequences of paraquat intoxication in mice:: Effects of α-synuclein over-expression
P. O. Fernagut et al.
SYNAPSE (2007)
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin
Nicole Exner et al.
JOURNAL OF NEUROSCIENCE (2007)
PINK1 mutants associated with recessive Parkinson's disease are defective in inhibiting mitochondrial release of cytochrome c
Hung-Li Wang et al.
NEUROBIOLOGY OF DISEASE (2007)
The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau et al.
NATURE CELL BIOLOGY (2007)
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
Berta Luzon-Toro et al.
HUMAN MOLECULAR GENETICS (2007)
Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
Cheng Wang et al.
JOURNAL OF NEUROSCIENCE (2007)
Mitochondrial DNA polymorphisms and the risk of Parkinson's disease in Taiwan
C. M. Chen et al.
JOURNAL OF NEURAL TRANSMISSION (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice
Tohru Kitada et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
Julia W. Pridgeon et al.
PLOS BIOLOGY (2007)
Familial parkinsonism and ophthalmoplegia from a mutation in the mitochondrial DNA helicase twinkle
Robert H. Baloh et al.
ARCHIVES OF NEUROLOGY (2007)
Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinson's disease
Celine Perier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Neuropathology of Parkinson's disease associated with the LRRK2 Ile1371Val mutation
Maria Teresa Giordana et al.
MOVEMENT DISORDERS (2007)
Altered axonal mitochondrial transport in the pathogenesis of Charcot-Marie-Tooth disease from mitofusin 2 mutations
Robert H. Baloh et al.
JOURNAL OF NEUROSCIENCE (2007)
The familial parkinsonism gene LRRK2 regulates neurite process morphology
David MacLeod et al.
NEURON (2006)
Understanding the molecular causes of Parkinson's disease
A. Wood-Kaczmar et al.
TRENDS IN MOLECULAR MEDICINE (2006)
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
L. Van den Bosch et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
C-terminal truncation and Parkinson's disease-associated mutations down-regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
Chou Hung Sim et al.
HUMAN MOLECULAR GENETICS (2006)
Creatine supplementation in Parkinson disease:: A placebo-controlled randomized pilot trial
A. Bender et al.
NEUROLOGY (2006)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Alfredo Ramirez et al.
NATURE GENETICS (2006)
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
Danling Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Reproducible nigral cell loss after systemic proteasomal inhibitor administration to rats
Bai-Yun Zeng et al.
ANNALS OF NEUROLOGY (2006)
Distribution of PINK1 and LRRK2 in rat and mouse brain
Jean-Marc Taymans et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Lack of nigrostriatal pathology in a rat model of proteasome inhibition
Amy B. Manning-Bog et al.
ANNALS OF NEUROLOGY (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress
Miratul M. K. Muqit et al.
JOURNAL OF NEUROCHEMISTRY (2006)
PINK1 protein in normal human brain and Parkinson's disease
S. Gandhi et al.
BRAIN (2006)
Mitochondria: Dynamic organelles in disease, aging, and development
David C. Chan
CELL (2006)
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
Ira E. Clark et al.
NATURE (2006)
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
Jeehye Park et al.
NATURE (2006)
Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease
Beisha Tang et al.
HUMAN MOLECULAR GENETICS (2006)
Axonal transport of mitochondria requires milton to recruit kinesin heavy chain and is light chain independent
Elizabeth E. Glater et al.
JOURNAL OF CELL BIOLOGY (2006)
Parkinson's disease brain mitochondrial complex I has oxidatively damaged subunits and is functionally impaired and misassembled
Paula M. Keeney et al.
JOURNAL OF NEUROSCIENCE (2006)
Intersecting pathways to neurodegeneration in Parkinson's disease:: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system
R Betarbet et al.
NEUROBIOLOGY OF DISEASE (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
Mitochondrial DNA deletions are abundant and cause functional impairment in aged human substantia nigra neurons
Y Kraytsberg et al.
NATURE GENETICS (2006)
Plasma membrane ion permeability induced by mutant α-synuclein contributes to the degeneration of neural cells
K Furukawa et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Susceptibility to rotenone is increased in neurons from parkin null mice and is reduced by minocycline
MJ Casarejos et al.
JOURNAL OF NEUROCHEMISTRY (2006)
Parkin enhances mitochondrial biogenesis in proliferating cells
Y Kuroda et al.
HUMAN MOLECULAR GENETICS (2006)
Mice lacking alpha-synuclein are resistant to mitochondrial toxins
P Klivenyi et al.
NEUROBIOLOGY OF DISEASE (2006)
Clinical heterogeneity of α-synuclein gene duplication in Parkinson's disease
K Nishioka et al.
ANNALS OF NEUROLOGY (2006)
Biochemical and pathological characterization of Lrrk2
BI Giasson et al.
ANNALS OF NEUROLOGY (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death
LJ Martin et al.
JOURNAL OF NEUROSCIENCE (2006)
Epidemiology of Parkinson's disease
Lonneke M. L. de Lau et al.
LANCET NEUROLOGY (2006)
Complex I deficiency primes Bax-dependent neuronal apoptosis through mitochondrial oxidative damage
C Perier et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration
WW Smith et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Promethazine protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity
C Cleren et al.
NEUROBIOLOGY OF DISEASE (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism
L Silvestri et al.
HUMAN MOLECULAR GENETICS (2005)
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
A Petit et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Mitochondrial DNA polymorphisms and risk of Parkinson's disease in Spanish population
C Huerta et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2005)
The GTPase dMiro is required for axonal transport of mitochondria to Drosophila synapses
XF Guo et al.
NEURON (2005)
Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease
KM Strauss et al.
HUMAN MOLECULAR GENETICS (2005)
Mitochondrial localization of the Parkinson's disease related protein DJ-1: implications for pathogenesis
L Zhang et al.
HUMAN MOLECULAR GENETICS (2005)
Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death
E Junn et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians
D Ghezzi et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2005)
Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability
A Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress
RH Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Rotenone induces oxidative stress and dopaminergic neuron damage in organotypic substantia nigra cultures
CM Testa et al.
MOLECULAR BRAIN RESEARCH (2005)
Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis
JC Greene et al.
HUMAN MOLECULAR GENETICS (2005)
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1
MS Goldberg et al.
NEURON (2005)
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity
A Yamamoto et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system
RH Andres et al.
CELL TRANSPLANTATION (2005)
Association of DJ-1 and parkin mediated by pathogenic DJ-1 mutations and oxidative stress
DJ Moore et al.
HUMAN MOLECULAR GENETICS (2005)
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice
JJ Palacino et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Enhanced substantia nigra mitochondrial pathology in human α-synuclein transgenic mice after treatment with MPTP
DD Song et al.
EXPERIMENTAL NEUROLOGY (2004)
DJ-1 has a role in antioxidative stress to prevent cell death
T Taira et al.
EMBO REPORTS (2004)
The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease
R Bandopadhyay et al.
BRAIN (2004)
β-amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase
AY Abramov et al.
JOURNAL OF NEUROSCIENCE (2004)
Systemic exposure to proteasome inhibitors causes a progressive model of Parkinson's disease
KSP McNaught et al.
ANNALS OF NEUROLOGY (2004)
The PARK8 locus in autosomal dominant parkinsonism: Confirmation of linkage and further delineation of the disease-containing interval
A Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2004)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization
RM Canet-Avilés et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
DJ-1 colocalizes with tau inclusions: A link between parkinsonism and dementia
P Rizzu et al.
ANNALS OF NEUROLOGY (2004)
Neuroprotective role of the reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice
LM Martins et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
EM Valente et al.
SCIENCE (2004)
Proteasome inhibition alters neural mitochondrial homeostasis and mitochondria turnover
PG Sullivan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Deranged neuronal calcium signaling and Huntington disease
I Bezprozvanny et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A
S Züchner et al.
NATURE GENETICS (2004)
Down regulation of DJ-1 enhances cell death by oxidative stress, ER stress, and proteasome inhibition
T Yokota et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)
α-Synuclein expression in HEK293 cells enhances the mitochondrial sensitivity to rotenone
M Orth et al.
NEUROSCIENCE LETTERS (2003)
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons
MS Goldberg et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism
V Bonifati et al.
NEUROLOGICAL SCIENCES (2003)
Parkin gene inactivation alters behaviour and dopamine neurotransmission in the mouse
JM Itier et al.
HUMAN MOLECULAR GENETICS (2003)
Caspase-3 dependent proteolytic activation of protein kinase Cδ mediates and regulates 1-methyl-4-phenylpyridinium (MPP+)-induced apoptotic cell death in dopaminergic cells:: relevance to oxidative stress in dopaminergic degeneration
S Kaul et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2003)
Dysfunction of mitochondrial complex I and the proteasome:: interactions between two biochemical deficits in a cellular model of Parkinson's disease
GU Höglinger et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease
JM van der Walt et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2003)
Parkin binds the Rpn10 subunit of 26S proteasomes through its ubiquitin-like domain
E Sakata et al.
EMBO REPORTS (2003)
Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death
F Darios et al.
HUMAN MOLECULAR GENETICS (2003)
Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
TB Sherer et al.
EXPERIMENTAL NEUROLOGY (2003)
Altered proteasomal function in sporadic Parkinson's disease
KS McNaught et al.
EXPERIMENTAL NEUROLOGY (2003)
Pathogenesis of Parkinson's disease:: Dopamine, vesicles and α-synuclein
J Lotharius et al.
NATURE REVIEWS NEUROSCIENCE (2002)
Resistance of α-synuclein null mice to the parkinsonian neurotoxin MPTP
W Dauer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Effects of coenzyme Q10 in early Parkinson disease -: Evidence of slowing of the functional decline
CW Shults et al.
ARCHIVES OF NEUROLOGY (2002)
Progression of nigrostriatal dysfunction in a parkin kindred:: an [18F] dopa PET and clinical study
NL Khan et al.
BRAIN (2002)
Inflammation in neurodegenerative disease - A double-edged sword
T Wyss-Coray et al.
NEURON (2002)
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines
AV Panov et al.
NATURE NEUROSCIENCE (2002)
The human dynamin-related protein OPA1 is anchored to the mitochondrial inner membrane facing the inter-membrane space
A Olichon et al.
FEBS LETTERS (2002)
The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice -: Paraquat and α-synuclein
AB Manning-Bog et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
An AAV-derived Apaf-1 dominant negative inhibitor prevents MPTP toxicity as antiapoptotic gene therapy for Parkinson's disease
H Mochizuki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
Y Suzuki et al.
MOLECULAR CELL (2001)
Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway
M Unoki et al.
ONCOGENE (2001)
Caspase-8 is an effector in apoptotic death of dopaminergic neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
A Hartmann et al.
JOURNAL OF NEUROSCIENCE (2001)
Bax ablation prevents dopaminergic neurodegeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease
M Vila et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin
A Mitsumoto et al.
FREE RADICAL RESEARCH (2001)
Chronic systemic pesticide exposure reproduces features of Parkinson's disease
R Betarbet et al.
NATURE NEUROSCIENCE (2000)
Cell death induced by MPTP, a substrate for monoamine oxidase B
A Nicotra et al.
TOXICOLOGY (2000)
Mitochondrial participation in ischemic and traumatic neural cell death
G Fiskum
JOURNAL OF NEUROTRAUMA (2000)
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy
C Delettre et al.
NATURE GENETICS (2000)
Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase
H Shimura et al.
NATURE GENETICS (2000)
Caspase-3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
A Hartmann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)
MPTP induces alpha-synuclein aggregation in the substantia nigra of baboons
NW Kowall et al.
NEUROREPORT (2000)