期刊
JOURNAL OF MEDICAL GENETICS
卷 42, 期 10, 页码 766-768出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jmg.2005.030999
关键词
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The MSH2* 1906G-->C mutation was recently shown to be a rare yet highly penetrant mutation leading to colorectal cancer. The mutation was only found among Ashkenazi Jewish individuals and lies on an extended haplotype that is common in that population. This study determined that the mutation probably arose between 11 and 22 generations ago, during the time when the Ashkenazim were living in eastern Europe.
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