期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 59, 期 2, 页码 1329-1333出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03937-14
关键词
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资金
- NIH [5P30 DK072506, R01AI104895, R21AI107302, P30 DK089507]
- Center for Vaccine Research of the University of Pittsburgh
Multidrug resistance constitutes a threat to the medical achievements of the last 50 years. In this study, we demonstrated the abilities of two de novo engineered cationic antibiotic peptides (eCAPs), WLBU2 and WR12, to overcome resistance from 142 clinical isolates representing the most common multidrug-resistant (MDR) pathogens and to display a lower propensity to select for resistant bacteria in vitro compared to that with colistin and LL37. The results warrant an exploration of eCAPs for use in clinical settings.
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