期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 58, 期 10, 页码 6273-6276出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02406-13
关键词
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资金
- IRD
- Agence Nationale du Developpement de la Recherche en Sante (ANDRS) Algeria (PNR) [08/ANDRS/2011]
- Fundacao para a Ciencia e a Tecnologia, Ministerio da Ciencia, Tecnologia e Ensino Superior, Portugal [SFRH/BPD/44082/2008]
- EU [FP7-261504 EDENext]
- EDENext Steering Committee [EDENext 0192]
- [GACR 13-07 500S]
We studied the development of antimony-resistant Leishmania infantum in natural vectors Lutzomyia longipalpis and Phlebotomus perniciosus to ascertain the risk of parasite transmission by sand flies. All three resistant strains produced fully mature late-stage infections in sand flies; moreover, the resistant phenotype was maintained after the passage through the vector. These results highlight the risk of circulation of resistant Leishmania strains and question the use of human drugs for treatment of dogs as Leishmania reservoirs.
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