期刊
EUROPEAN JOURNAL OF NUTRITION
卷 44, 期 7, 页码 452-457出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-005-0555-x
关键词
Rosa roxburghii; antioxidants; glutathione redox state; polyphenols; antioxidant capacity
Background Rosa roxburghii (RR) is a plant of which the fruit juice has been used as a medicinal remedy for a variety of diseases. It has been proposed that the putative beneficial properties are related to its antioxidant potential. Aim of study We investigated the contribution of a supplemented RR fruit sample on the antioxidant status in a cohort of healthy humans. Methods A total of 36 young, healthy and non-smoking individuals were recruited for this randomised placebo-controlled, single-blind trial. The study was diet controlled over a five-week period with a two week run-in period before participants daily received a placebo or an encapsulated supplement of RR sample. Total antioxidant capacity, glutathione redox state, glutathione reductase, glutathione peroxidase, superoxide dismutase and 8-OHdG levels were measured. Results RR supplementation significantly increased plasma antioxidant capacity (p = 0.04) and GSH:GSSG ratios in blood (p = 0.03). No significant changes in 8-OHdG levels, total glutathione levels or antioxidant modulating enzymes were detected suggesting that the observed shift of the glutathione redox state probably occurs via the antioxidant mediated protection of GSH. Conclusions We conclude that these findings support the putative beneficial properties that have been linked to Rosa roxburghii as a dietary supplement that can enhance antioxidant status.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据