期刊
ACTA ANAESTHESIOLOGICA SCANDINAVICA
卷 49, 期 9, 页码 1287-1292出版社
WILEY
DOI: 10.1111/j.1399-6576.2005.00841.x
关键词
arterial pressure; cardiac output; central venous pressure; pulmonary wedge pressure
Background: The stroke volume (SV) of the heart depends on the diastolic volume but, for the intact organism, central pressures are applied widely to express the filling of the heart. Methods: This study evaluates the interdependence of SV and thoracic electrical admittance of thoracic fluid content (TA) vs. the central venous (CVP), mean pulmonary artery (MPAP) and pulmonary artery wedge (PAWP) pressures during head-up (HUT) and head-down (HDT) tilt in nine healthy humans. Results: From the supine position to 20 degrees HDT, SV [112 +/- 18 ml; mean +/- standard deviation (SD)], TA (30.8 +/- 7.1 mS) and CVP (3.6 +/- 0.9 mmHg) did not change significantly, whereas MPAP (from 13.9 +/- 2.7 to 16.1 +/- 2.5 mmHg) and PAWP (from 8.8 +/- 3.4 to 11.3 +/- 2.5 mmHg; P < 0.05) increased. Conversely, during 70 degrees HUT, SV (to 65 +/- 24 ml) decreased, together with CVP (to 0.9 +/- 1.4 mmHg; P < 0.001), MPAP (to 9.3 +/- 3.8 mmHg; P < 0.01), PAWP (to 0.7 +/- 3.3 mmHg; P < 0.001) and TA (to 26.7 +/- 6.8 mS; P < 0.01). However, from 20 to 50 min of HUT, SV decreased further (to 48 +/- 21 ml; P < 0.001), whereas the central pressures did not change significantly. Conclusions: During both HUT and HDT, SV of the heart changed with the thoracic fluid content rather than with the central vascular pressures. These findings confirm that the function of the heart relates to its volume rather than to its so-called filling pressures.
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