期刊
NATURE REVIEWS DRUG DISCOVERY
卷 4, 期 10, 页码 834-844出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrd1852
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资金
- NINDS NIH HHS [R01 NS043095-04, R01 NS043095-05, R01 NS049136, R01 NS043095] Funding Source: Medline
Chronic (neuropathic) pain is one of the most widespread and intractable of human complaints, as well as being one of the most difficult syndromes to treat successfully with drugs or surgery. The development of new therapeutic approaches to the treatment of painful neuropathies requires a better understanding of the mechanisms that underlie the development of these chronic pain syndromes. It is clear that inflammatory responses often accompany the development of neuropathic pain, and here we discuss the idea that chemokines might be key to integrating the development of pain and inflammation and could furnish new leads in the search for effective analgesic agents for the treatment of painful neuropathies.
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