期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 58, 期 9, 页码 5567-5569出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.03408-14
关键词
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资金
- National Heart, Lung, and Blood Institute [R01 HL106786]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01 AI083125]
We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent doses of thioridazine when given in combination with the Denver regimen against acute murine tuberculosis. We found a trend toward a positive impact of thioridazine on the bacterial clearance and lowering relapse rates of the combined standard TB chemotherapy.
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