期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 5, 页码 1389-1395出版社
AMER PSYCHOLOGICAL ASSOC/EDUCATIONAL PUBLISHING FOUNDATION
DOI: 10.1037/0735-7044.119.5.1389
关键词
memory; cognition; obesity; type 2 diabetes mellitus; Zucker rats
资金
- PHS HHS [41256] Funding Source: Medline
The genetically obese Zucker rat is a widely investigated model of pathological changes associated with type 2 diabetes. To assess cognitive function, obese and lean Zucker rats were tested on a variable-interval delayed alternation test of learning and memory. There were no group differences in learning the alternation rule or at short intervals, but obese rats were impaired at longer intervals where performance is hippocampus dependent. Plasma membrane association of the insulin sensitive glucose transporter, GLUT4, was reduced in the hippocampus of obese rats in the absence of changes in total GLUT4 and insulin receptor expression. These results parallel those of human studies in pointing to the susceptibility of the hippocampus and related structures to the adverse environment of diabetes mellitus.
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