期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 4, 页码 1952-1956出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02084-12
关键词
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资金
- European Union [260644]
- European Virus Archive (EVA) project (European FP7 Capacities Project) [228292]
- Convenant K. U. Leuven-Radboud University Nijmegen framework [GOA/10/014]
- FWO Krediet aan Navorsers [1.5.206.11]
Although the genus Enterovirus contains many important human pathogens, there is no licensed drug for either the treatment or the prophylaxis of enterovirus infections. We report that fluoxetine (Prozac)-a selective serotonin reuptake inhibitor-inhibits the replication of human enterovirus B (HEV-B) and HEV-D but does not affect the replication of HEV-A and HEV-C or human rhinovirus A or B. We show that fluoxetine interferes with viral RNA replication, and we identified viral protein 2C as the target of this compound.
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