期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 58, 期 2, 页码 1161-1166出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02165-13
关键词
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资金
- European Foundation Initiative on Neglected Tropical Diseases (EFINTD) [I/83994]
- MRC [MR/J01477X/1] Funding Source: UKRI
- Medical Research Council [MR/J01477X/1] Funding Source: researchfish
Buruli ulcer, an ulcerating skin disease caused by Mycobacterium ulcerans infection, is common in tropical areas of western Africa. We determined the clinical and microbiological responses to administration of rifampin and streptomycin for 2 weeks followed by administration of rifampin and clarithromycin for 6 weeks in 43 patients with small laboratory-confirmed Buruli lesions and monitored for recurrence-free healing. Bacterial load in tissue samples before and after treatment for 6 and 12 weeks was monitored by semiquantitative culture. The success rate was 93%, and there was no recurrence after a 12-month follow-up. Eight percent had a positive culture 4 weeks after antibiotic treatment, but their lesions went on to heal. The findings indicate that rifampin and clarithromycin can replace rifampin and streptomycin for the continuation phase after rifampin and streptomycin administration for 2 weeks without any apparent loss of efficacy.
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