期刊
JOURNAL OF CLINICAL INVESTIGATION
卷 115, 期 10, 页码 2656-2664出版社
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI26373
关键词
-
资金
- NIA NIH HHS [R01 AG015393, AG15393] Funding Source: Medline
- NINDS NIH HHS [F32 NS047855, NS047855] Funding Source: Medline
Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell stress response, the unfolded protein response, which is aimed initially at compensating for damage but can eventually trigger cell death if ER dysfunction is severe or prolonged. The mechanisms by which ER stress leads to cell death remain enigmatic, with multiple potential participants described but little clarity about which specific death effectors dominate in particular cellular contexts. Important roles for ER-initiated cell death pathways have been recognized for several diseases, including hypoxia, ischemia/reperfusion injury, neurodegeneration, heart disease, and diabetes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据