期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 4, 页码 1938-1940出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01461-12
关键词
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Colistin pharmacokinetics were prospectively studied after intravenous administration of colistin methanesulphonate in critically ill patients without central nervous system infection (controls, n = 5) and in patients with external ventricular drain-associated ventriculitis after intravenous administration (EVDViv, n = 3) or combined intravenous/intraventricular administration (EVDVcomb, n = 4). Cerebrospinal fluid (CSF)/serum colistin concentration ratios were higher in EVDViv than in control patients (11% versus 7%, P <= 0.05) and in EVDVcomb compared to all other patients (P < 0.0001). CSF colistin concentrations above the MIC of 0.5 mu g/ml were achieved only in EVDVcomb patients.
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