期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 58, 期 2, 页码 1183-1186出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01745-13
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资金
- Merck Co., Inc.
Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular stress responses induced by high fluconazole concentrations and mediated by Hsp90 and calcineurin play an important role in this phenomenon.
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