Microwave-assisted solvent-free heterocyclic synthesis

In this review, we report the important role of solvent-free conditions coupled with microwave activation and their advantages in heterocyclic synthesis. This eco-friendly approach, which was found application in facile organic synthesis, is applied to the rapid assembly of heteroatom organic compounds via cycloaddition and cyclocondensation reactions. Combinatorial heterocyclic synthesis under solvent-free conditions is described having allowed to build a library of such heterocyclic compounds of pharmacological interest. (c) 2005 Elsevier B.V. All rights reserved.