期刊
BIOLOGICAL CHEMISTRY
卷 386, 期 10, 页码 989-997出版社
WALTER DE GRUYTER GMBH
DOI: 10.1515/BC.2005.115
关键词
anaerobic aromatic metabolism; benzoyl-CoA reductase; 4-hydroxybenzoyl-CoA reductase; phenylphosphate carboxylase; phenylphosphate synthase
Aerobic bacteria use molecular oxygen as a common co-substrate for key enzymes of aromatic metabolism. In contrast, in anaerobes all oxygen-dependent reactions are replaced by a set of alternative enzymatic processes. The anaerobic degradation of phenol to a non-aromatic product involves enzymatic processes that are uniquely found in the aromatic metabolism of anaerobic bacteria: (i) ATP-dependent phenol carboxylation to 4-hydroxybenzoate via a phenylphosphate intermediate (biological Kolbe-Schmitt carboxylation); (ii) reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA; and (iii) ATP-dependent reductive dearomatization of the key intermediate benzoyl-CoA in a 'Birch-like' reduction mechanism. This review summarizes the results of recent mechanistic studies of the enzymes involved in these three key reactions.
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