期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 8, 页码 4072-4076出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02266-12
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资金
- National Science Council of Taiwan [NSC-00-2321-B-002-021, NSC100-3111-B-400-001, NSC101-2311-B-005-002]
Genetic determinants of a bla(NDM-1)-positive, multidrug-resistant bacterial isolate that caused active infection was investigated by DNA sequencing. Two plasmids, pKOX_NDM1 and pKOX-R1, were identified for the Klebsiella oxytoca strain E718. Sequence annotation revealed a bla(NDM-1) gene in pKOX_NDM1 and two extended-spectrum beta-lactamase producers (bla(CTX-M-3) and bla(SHV-12)) and a wide array of resistance genes in pKOX-R1. These findings highlight the difficulty in treating multidrug-resistant bacterial infections and the potential danger of emerging resistant enterobacteria.
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