期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 9, 页码 4587-4589出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00543-13
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资金
- Consejeria de Salud of the Junta de Andalucia [PI-0044-2011]
- Ministerio de Economia y Competitividad, Instituto de Salud Carlos III - European Development Regional Fund A way to achieve Europe (ERDF), Spanish Network for the Research in Infectious Diseases [REIPI RD12/0015]
- Ministerio de Economia y Competitividad of Spain [CP11/00314]
The fitness and virulence costs associated with the clinical acquisition of colistin resistance by Acinetobacter baumannii were evaluated. The growth of strain CR17 (colistin resistant) was less than that of strain CS01 (colistin susceptible) when the strains were grown in competition (72-h competition index, 0.008). In a murine sepsis model, CS01 and CR17 reached spleen concentrations when coinfecting of 9.31 and 6.97 log(10) CFU/g, respectively, with an in vivo competition index of 0.016. Moreover, CS01 was more virulent than CR17 with respect to mortality and time to death.
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