期刊
NATURE NEUROSCIENCE
卷 8, 期 10, 页码 1289-1291出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1548
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- NIDDK NIH HHS [DK-060711, DK-07386] Funding Source: Medline
Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide ( AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis.
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