期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 4, 页码 1918-1920出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.02378-12
关键词
-
资金
- NIH [R01 AI073289-01]
Candida biofilm infections pose an increasing threat in the health care setting due to the drug resistance associated with this lifestyle. Several mechanisms underlie the resistance phenomenon. In Candida albicans, one mechanism involves drug impedance by the biofilm matrix linked to beta-1,3 glucan. Here, we show this is important for other Candida spp. We identified beta-1,3 glucan in the matrix, found that the matrix sequesters antifungal drug, and enhanced antifungal susceptibility with matrix beta-1,3 glucan hydrolysis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据