期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 4, 页码 1921-1925出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00007-13
关键词
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资金
- NIH [RC2 AR058971-01, R21 EB014594]
- Wisconsin Agricultural Experiment Station [WIS01607]
- Clinical and Translational Science Award program, and through the NIH National Center for Advancing Translational Sciences [UL1TR000427]
Biofilm formation by Pseudomonas aeruginosa has been implicated in the pathology of chronic wounds. Both the D and L isoforms of tryptophan inhibited P. aeruginosa biofilm formation on tissue culture plates, with an equimolar ratio of D and L isoforms producing the greatest inhibitory effect. Addition of D-/L-tryptophan to existing biofilms inhibited further biofilm growth and caused partial biofilm disassembly. Tryptophan significantly increased swimming motility, which may be responsible in part for diminished biofilm formation by P. aeruginosa.
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