期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 8, 页码 4050-4052出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00252-13
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资金
- National Science Council, Taiwan
- National Taiwan University Hospital Hsinchu Branch
The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid beta-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich peptide S1 were diminished at high salt concentrations, whereas the activities of its beta-naphthylalanine end-tagged variants were less affected.
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