期刊
FORENSIC SCIENCE INTERNATIONAL
卷 153, 期 1, 页码 53-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2005.04.018
关键词
2,4-dichlorophenoxyacetic acid (2,4-D); 2,4-dichlorophenol (2,4-DCP); HPLC; kidney accumulation; rat
The accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) and its metabolite 2,4-dichlorophenol (2,4-DCP) in the kidneys of rats was investigated. Male and female Sprague-Dawley rats were given 2,4-D in drinking water and food for 30 days. Group A (control group) was fed a normal diet, Group B Was fed 50 ppm 2,4-D in 15 g food, Group C received 100 ppm 2,4-D in 15 g food, Group D received 25 ppm 2,4-D in 15 ml drinking water and Group E was given 50 ppm 2,4-D in 15 ml of drinking water. Levels of 2,4-D and 2,4-DCP in kidneys were determined using high performance liquid chromatography (HPLC). It was observed that at low doses of 2,4-D, the metabolite, 2,4-DCP found in the kidneys. (C) 2005 Elsevier Ireland Ltd. All rights reserved.
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