期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 127, 期 39, 页码 13598-13610出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja053365y
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资金
- NIGMS NIH HHS [GM-33049] Funding Source: Medline
The structure elucidation of (+)-amphidinolide A, a cytotoxic macrolide, has been accomplished by employing a combination of NMR chemical shift analysis and total synthesis. The 20-membered ring of amphidinolide A was formed by a ruthenium-catalyzed alkene-alkyne coupling to forge the C15-C16 bond. Using the reported structure 1 as a starting point, a number of diastereomers of amphidinolide A were prepared. Deviations of the chemical shift of key protons in each isomer relative to the natural material were used as a guide to determine the locations of the errors in the relative stereochemistry. The spectroscopic data for the synthetic and natural material are in excellent agreement.
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