期刊
DEVELOPMENTAL BRAIN RESEARCH
卷 159, 期 2, 页码 149-154出版社
ELSEVIER
DOI: 10.1016/j.devbrainres.2005.07.002
关键词
brain development; chemoattraction; choline; hippocampus; pregnancy
资金
- NIA NIH HHS [AG09525, P01 AG009525] Funding Source: Medline
- NIDDK NIH HHS [DK55865, R01 DK055865, DK56350, P30 DK056350] Funding Source: Medline
- NIEHS NIH HHS [ES012997, ES10126, R21 ES012997, P30 ES010126] Funding Source: Medline
Alterations in maternal dietary choline availability during days 12-17 of pregnancy led to an increase in the level of immunoreactive netrin-1 and a decrease in the level of DCC protein in the developing fetal mouse brain hippocampus compared with controls. Changes in the expression of cell migration cues during development could account for some of the lifelong consequences of maternal dietary choline availability for cognitive and memory processes. (c) 2005 Elsevier B.V. All rights reserved.
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