期刊
TETRAHEDRON LETTERS
卷 46, 期 41, 页码 7051-7053出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.08.043
关键词
quinazolin-4(3H)-ones; silica sulfuric acid; catalysis; solvent free
Quinazolin-4(3H)-one derivatives were synthesized successfully via a one-pot, three component reaction of isatoic anhydride and an orthoester with ammonium acetate or a primary amine catalyzed by silica sulfuric acid under solvent-free conditions. This is the first report on the synthesis of 2-substituted quinazolin-4(3H)-ones by this procedure. (c) 2005 Elsevier Ltd. All rights reserved.
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