期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 56, 期 6, 页码 3395-3398出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.06364-11
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资金
- National Center for Research Resources [KL2 RR024154]
We tested two-drug combinations of doripenem, colistin, gentamicin, and doxycycline against 12 carbapenemase-producing Klebsiella pneumoniae (KPC) isolates by time-kill. The combination of doripenem and colistin reduced the starting inocula by 2 logs for each isolate (range, 2.02 to 6.01 log(10)) and was bactericidal and synergistic against 75 and 50%, respectively. Among colistin- and pan-drug-resistant isolates, synergy was identified in 60 and 67%, respectively. All other combinations were inferior. We are currently evaluating the combination of doripenem and colistin as a frontline therapy for KPC infection.
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