期刊
BLOOD
卷 106, 期 8, 页码 2879-2883出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2005-02-0716
关键词
-
类别
资金
- NICHD NIH HHS [P30 HD018655] Funding Source: Medline
- NIDDK NIH HHS [R01 DK053813, R01 DK053813-10, R01 DK 066373, R01 DK53813, R01 DK066373, K01 DK02804, R01 DK062474] Funding Source: Medline
Mammalian northeme iron absorption requires reduction of dietary iron for uptake by the divalent metal ion transport system in the intestine. This was thought to be mediated by duodenal cytochrome b (Cybrd1), a ferric reductase enzyme resident on the luminal surface of intestinal absorptive cells. To test its importance in vivo, we inactivated the murine Cybrd1 gene and assessed tissue iron stores in Cybrd1-null mice. We found that loss of Cybrd1 had little or no impact on body iron stores, even in the setting of iron deficiency. We conclude that other mechanisms must be available for the reduction of dietary iron.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据