期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 148, 期 1, 页码 78-87出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2005.04.005
关键词
MPTP; 6-OHDA; substantia nigra; Parkinson's disease; working memory; habit learning; water maze
This study compares histological, neurochemical, behavioral, motor and cognitive alterations as well as mortality of two models of Parkinson's disease in which 100 mu g 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP) or 6 mu g 6-hydroxydopamine (6-OHDA) was bilaterally infused into the central region of the substantia nigra, compact part, of adult male Wistar rats. Both neurotoxins caused a significant loss of nigral tyrosine hydroxylase-immunostained cells and striatal dopamine depletion, but 6-OHDA caused more widespread and intense cell loss, more intense body weight loss and more mortality than MPTP. Both 6-OHDA- and MPTP-lesioned rats presented similar deficits in performing a working memory and a cued version of the Morris water maze task and few exploratory/motor alterations in the open field and catalepsy tests. However, rats presented a significant and transitory increase in locomotor activity after the MPTP lesion and a hypolocomotor behavior tended to be present after the 6-OHDA lesion. The picture of mild motor effects and robust impairment of habit learning and spatial working memory observed in MPTP-lesioned rats models the early phase of Parkinson's disease. (c) 2005 Elsevier B.V. All rights reserved.
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