期刊
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
卷 57, 期 1, 页码 220-228出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01619-12
关键词
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资金
- National Natural Science Foundation of China [90813012, 20932003, 21272102, 31200584, 21272108, 81202400]
- Key National S&T Program Major New Drug Development of the Ministry of Science and Technology [2012ZX09504001-003]
The extensive use and misuse of antibiotics in medicine result in the emergence of multidrug-resistant bacteria, creating an urgent need for the development of new chemotherapeutic agents. Nowadays, antimicrobial peptides are widely recognized as a class of promising candidates with activity against multidrug-resistant bacteria. NK-18 is a truncated peptide derived from NK-Lysin, an effector of cytotoxic T cells and natural killer cells. In this study, we studied the antibacterial mechanism of action of NK-18. The results revealed that NK-18 has potent antibacterial activity against Escherichia coli and Staphylococcus aureus. According to our findings, NK-18 is membrane active and its target of action is not only the bacterial membrane but also the DNA in the cytoplasm. The double targets of NK-18 make it difficult for bacteria to generate resistance, which may present a new strategy to defend against multidrug-resistant bacteria and provide a new lead in the design of potent antimicrobial peptides with therapeutic application in the presence of increasing resistance to conventional antibiotics.
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