期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 20, 页码 4585-4588出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.06.102
关键词
DNA cleavage; carbon radicals; ROS; hydrogen peroxide; photolysis
DNA strand scission is produced by the ambient light photolysis of CpFe(CO)(2)Ph and H2O2, a result that shows potential as a means of targeting tumors, due to the high levels of hydrogen peroxide in cancer cells. This cleavage process is dependent on the concentration of both CpFe(CO)(2)Ph and H2O2, and preliminary experiments implicate both carbon-centered radicals and reactive oxygen species. (c) 2005 Elsevier Ltd. All rights reserved.
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