期刊
JOURNAL OF NEUROSCIENCE METHODS
卷 148, 期 1, 页码 71-77出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneumeth.2005.04.017
关键词
brain computer interface (BCI); autonomous experimentation; cortical neurons; neural prosthesis
资金
- NCRR NIH HHS [RR 00166] Funding Source: Medline
- NINDS NIH HHS [R01 NS12542] Funding Source: Medline
To perform neurobiological experiments on freely behaving primates, we have developed a miniature battery-powered implantable computer capable of recording and stimulating through chronic electrodes in the cortex. The device has: (1) an analog front end with a four-pole bandpass filter (500 Hz-5 kHz), programmable gain and offset nulling; (2) an analog-to-digital converter to sample the data at 11.7 ksps; (3) a programmable microcontroller to discriminate spikes in real time and perform computations; (4) a stimulator to deliver biphasic current pulses of up to 100 mu A with variable pulse width and frequency; (5) a 4 Mbit non-volatile memory to store biological data; (6) a 57.6 kbps infrared data link for wireless communications with a hand-held or desktop computer. The device is enclosed in a 5.5 cm x 5 cm x 3 cm titanium casing on the monkey's head along with a 3.3 V lithium battery and an array of cortical electrodes. In in vivo tests, the device was able to record stable cell discharge continuously for time periods of a week or more. After downloading the parameters for recording, stimulation, discrimination, and other computations, the device is capable of operating autonomously, delivering stimuli to one electrode triggered by spikes recorded at a separate site. (c) 2005 Published by Elsevier B.V.
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