期刊
JOURNAL OF CELLULAR BIOCHEMISTRY
卷 96, 期 3, 页码 439-446出版社
WILEY
DOI: 10.1002/jcb.20522
关键词
prostate cancer; bone metastasis; cancer therapy
资金
- NCI NIH HHS [P01 CA093900-01A2, 2 P50 CA69568-06A1, R01 CA102872] Funding Source: Medline
The pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous hurdle to overcome in designing novel cancer therapeutics. New targets of therapy are essential if we are to effectively overcome the evasiveness of cancer. The interaction between the turner cell and the surrounding microenvironment creates a vicious cycle that perpetuates disease survival and progression. The future of cancer therapy resides in the ability to focus on the recruited and exploited relationships of the cancer cell with the host environment. These therapies target cancer cell growth early and interrupt the vicious cycle that is created by the tumor cells interacting with bone components by inhibiting osteoclasts, osteoblasts, stromal cells, and endothelial cells. They alter the bone microenvironment, creating a hostile soil that prevents the seed from developing into bone metastases and represent a potential new platform for the development of Prostate cancer therapeutics.
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