期刊
SCHIZOPHRENIA RESEARCH
卷 78, 期 2-3, 页码 127-130出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2005.05.002
关键词
schizophrenia; trace amine receptor; linkage disequilibrium; haplotype-tagging SNP
类别
Recent study of linkage disequilibrium mapping showed one of the trace amine receptor (TRAR) genes, TRAR4, was associated with schizophrenia. We conducted a replication study of TRAR4 with schizophrenia in Japanese patients. We used two large independent sets of samples in a first-set analysis (cases=405, controls=401) and second-set analysis (cases=503, controls=440). In the first-set analysis, one Marker (Marker5) showed a significant association, but this significance was not seen in the second-set analysis. Our results indicate that TRAR4 may not play a major role in Japanese schizophrenia patients, and that it is important to examine the possibility of false positives in genetic association analysis. (c) 2005 Elsevier B.V. All rights reserved.
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