期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 20, 页码 4456-4458出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.07.047
关键词
flavonoids; trifluoromethylation
3-Trifluoromethylflavonoid derivatives were prepared for the first time by trifluoromethylation of 3-iodoflavonoid derivatives. Other C ring and B ring trifluoromethylated flavonoid derivatives were also prepared. All the compounds were tested for their effect on the U2OS cell cycle in vitro. Bistrifluoromethylated apigenin derivative 13 showed the strongest activity against the cell growth. (c) 2005 Elsevier Ltd. All rights reserved.
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